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Journal of Zhejiang University SCIENCE A

ISSN 1673-565X(Print), 1862-1775(Online), Monthly

Analytical solution of ground-borne vibration due to a spatially periodic harmonic moving load in a tunnel embedded in layered soil

Abstract: In this study, we propose a novel coupled periodic tunnel–soil analytical model for predicting ground-borne vibrations caused by vibration sources in tunnels. The problem of a multilayered soil overlying a semi-infinite half-space was solved using the transfer matrix method. To account for the interactions between the soil layer and tunnel structure, the transformation characteristics between cylindrical waves and plane waves were considered and used to convert the corresponding wave potentials into forms in terms of the Cartesian or cylindrical coordinate system. The induced ground-borne vibration was obtained analytically by applying a spatially periodic harmonic moving load to the tunnel invert. The accuracy and efficiency of the proposed model were verified by comparing the results under a moving constant and harmonic load with those from previous studies. Subsequently, the response characteristics under a spatially periodic harmonic moving load were identified, and the effects of a wide range of factors on the responses were systematically investigated. The numerical results showed that moving and Doppler effects can be caused by a spatially periodic harmonic moving load. The critical frequency and frequency bandwidth of the response are affected by the load type, frequency, velocity, and wavenumber in one periodicity length. Increasing the tunnel depth is an efficient way to reduce ground-borne vibrations. The effect of vibration amplification on the free surface should be considered to avoid excessive vibration levels that disturb residents.

Key words: Coupled tunnel‍–‍soil model; Spatially periodic load; Transfer matrix method; Wave transformation; Parametric analysis

Chinese Summary  <15> 伊维菌素抑制NLRP3炎症小体可改善博来霉素诱导的肺纤维化

Mai A. ABD-ELMAWLA1,Heba R. GHAIAD1,Enas S. GAD2,3,Kawkab A. AHMED4,Maha ABDELMONEM1
1埃及开罗大学药学院生物化学系,埃及开罗,11562
2费萨尔国王大学药学院药学系,沙特阿拉伯哈萨,31982
3埃及西奈大学药学院药理毒理学系,埃及伊斯梅利亚,45511
4埃及开罗大学兽医学院病理学系,埃及开罗,12211
摘要:伊维菌素是美国食品药品监督管理局(FDA)批准的抗寄生虫剂,具有抗病毒和抗炎特性。尽管最近有研究表明伊维菌素在呼吸系统损伤中可能具有抗炎活性,但其对肺纤维化(PF)的潜在影响尚未得到验证。本研究旨在探讨伊维菌素(0.6 mg/kg)在PF大鼠模型中减轻博来霉素诱导的生化紊乱和组织学变化的效果。这可用于验证伊维菌素作为治疗特发性PF在临床上的效用。在本研究中,伊维菌素减轻了博来霉素诱发的肺损伤,表现为炎症细胞浸润减少以及炎症和纤维化评分降低。值得注意的是,伊维菌素减少了胶原纤维的沉积并抑制了转化生长因子-β1(TGF-β1)和纤连蛋白的表达,突显了其抗纤维化活性。本研究首次揭示伊维菌素可以抑制NOD样受体家族含吡啶结构域蛋白3(NLRP3)炎症小体,表现为NLRP3和含有半胱天冬酶募集结构域的凋亡相关斑点样蛋白(ASC)基因的表达减少,以及白细胞介素-1β(IL-1β)水平的下降。此外,伊维菌素抑制细胞内核因子-κB(NF-κB)和缺氧诱导因子-1α(HIF-1α)蛋白的表达,同时降低氧化应激和凋亡标志物的水平。本研究表明,伊维菌素可以改善博来霉素引起的肺部炎症和纤维化,并且部分功能是通过下调TGF-β1和纤连蛋白以及通过调节HIF-1α和NF-κB的表达抑制NLRP3炎性小体来介导的。

关键词组:气管内滴注;免疫组化;转化生长因子-β1(TGF-β1);核转录因子-κB(NF-κB);肺纤维化


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DOI:

10.1631/jzus.A2200385

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On-line Access:

2023-07-20

Received:

2022-08-11

Revision Accepted:

2022-12-16

Crosschecked:

2023-07-20

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