Abstract: The establishment of a dependable electrophysiological detection platform is paramount for cardiology and neuroscience research. In the past decade, devices based on micro and nanoscale sensing and control technologies have been developed to construct electrophysiological platforms. Their unique morphological advantages and novel processing methods offer the potential for high-throughput, high-fidelity electrical signal recording. In this review, we analyze the structure, transmembrane strategies, and electrophysiological detection methods of active/passive micro and nano sensing platforms. We also provide an outlook on their vast potential for development in light of the opportunities and challenges facing micro and nano sensing technology, with the aim of pushing for higher-level electrophysiological platform construction to meet the needs of experimental research and clinical applications.

Key words: Intracellular electrophysiology; Micro-nano biosensing platforms; Cardiology and neuroscience; Intracellular action potentials

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