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Journal of Zhejiang University SCIENCE A

ISSN 1673-565X(Print), 1862-1775(Online), Monthly

Transfer relation between subgrade frost heave and slab track deformation and vehicle dynamic response in seasonally frozen ground

Abstract: Subgrade frost heave in seasonally frozen ground can greatly influence the safety and smooth running of high-speed trains and the service performance of track structures. In this study, we used a static model to: (1) investigate track‍–‍subgrade frost heave and develop a dynamic model of vehicle‍–‍track‍–‍subgrade frost heave; (2) explore the transfer relation between subgrade frost heave and track structure deformation; (3) examine the characteristics of interlayer debonding; (4) study the influence of subgrade frost heave on the dynamic response of vehicles in high-speed railways in seasonally frozen regions. A Fourier series was used to fit the frost heave waveform and simulate the behavior of subgrade uneven frost heave using data collected on-site. The results show: (i) The position of frost heave significantly affects the transfer of deformation to a slab track. The largest deformation of the track slab, with the amplitude transfer ratio reaching 20%, was recorded when the frost heave occurred near the joint of the base plate. (ii) At the same frost heave amplitude, long-wave frost heave causes smaller deformation and debonding of the track structure than short-wave frost heave. In the wavelength range of 10‍–‍30 m, the main frequency of the acceleration spectral density was concentrated between 3.5 and 3.7 Hz, with larger frost heave wavelengths producing smaller superposition on the vertical acceleration of the vehicle. (iii) The maximum wheel–rail force occurs when the front bogie passes the frost heave peak, with greater frost heave amplitudes producing greater wheel‍–‍rail force. From these results, we conclude there is a clear need to control the frost heave deformation of the track to reduce the dynamic response of the vehicle and in turn improve train operations.

Key words: Slab track; Subgrade frost heave; Transfer relation; Vehicle–track–subgrade coupling; Dynamic response

Chinese Summary  <99> 血红素加氧酶1与骨关节炎软骨下破骨细胞失活的相关研究

储淼1,2,陈广东1,陈楷1,3,朱鹏飞1,王振4,钱忠来1,陶华强1,徐耀增1,耿德春1
1苏州大学第一附属医院骨科,中国苏州市,215006
2宜兴市人民医院骨科,中国宜兴市,214299
3海安人民医院骨科,中国海安市,226600
4上海交通大学医学院附属苏州九龙医院骨科,中国苏州市,215028
摘要:骨关节炎(OA)是一种老年慢性进行性骨关节病。破骨细胞活化在早期骨关节炎软骨下骨丢失的发生中起着至关重要的作用。然而,骨性关节炎中破骨细胞分化的具体机制尚不清楚。在本研究中,从基因表达综合库(GEO)中筛选了与OA疾病进展和破骨细胞活化相关的基因表达谱。采用GEO2R和Funrich分析工具寻找差异表达基因(DEGs)。富集分析结果表明,化学致癌作用、活性氧和氧化应激反应主要参与OA软骨下骨的破骨细胞分化。此外,还鉴定了14个与氧化应激相关的DEGs。选择排名第一的差异基因血红素加氧酶1(HMOX1)进行进一步验证。相关结果显示,OA软骨下骨破骨细胞活化过程中伴随着HMOX1的下调。在体外实验中发现,鼠尾草酚通过靶向HMOX1,上调抗氧化蛋白的表达来抑制破骨细胞的形成。同时,在体内发现鼠尾草酚通过抑制软骨下骨破骨细胞的激活来减轻OA的严重程度。综上所述,软骨下骨氧化还原失稳态引起的破骨细胞活化是骨性关节炎进展的重要途径。在软骨下破骨细胞中靶向HMOX1可为早期OA的治疗提供新的见解。

关键词组:破骨细胞;氧化应激;骨关节炎(OA);血红素加氧酶1(HMOX1);鼠尾草酚


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DOI:

10.1631/jzus.A2300303

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On-line Access:

2024-02-01

Received:

2023-06-07

Revision Accepted:

2023-09-24

Crosschecked:

2024-02-01

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