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Journal of Zhejiang University SCIENCE A

ISSN 1673-565X(Print), 1862-1775(Online), Monthly

Parameter matching and optimization of hybrid excavator swing system

Abstract: In this study, a novel synergistic swing energy-regenerative hybrid system (SSEHS) for excavators with a large inertia slewing platform is constructed. With the SSEHS, the pressure boosting and output energy synergy of multiple energy sources can be realized, while the swing braking energy can be recovered and used by means of hydraulic energy. Additionally, considering the system constraints and comprehensive optimization conditions of energy efficiency and dynamic characteristics, an improved multi-objective particle swarm optimization (IMOPSO) combined with an adaptive grid is proposed for parameter optimization of the SSEHS. Meanwhile, a parameter rule-based control strategy is designed, which can switch to a reasonable working mode according to the real-time state. Finally, a physical prototype of a 50-t excavator and its AMESim model is established. The semi-simulation and semi-experiment results demonstrate that compared with a conventional swing system, energy consumption under the 90° rotation condition could be reduced by about 51.4% in the SSEHS before parameter optimization, while the energy-saving efficiency is improved by another 13.2% after parameter optimization. This confirms the effectiveness of the SSEHS and the IMOPSO parameter optimization method proposed in this paper. The IMOPSO algorithm is universal and can be used for parameter matching and optimization of hybrid power systems.

Key words: Hybrid system; Energy regeneration; Swing braking energy; Parameter optimization; Improved multi-objective particle swarm optimization (IMOPSO); Adaptive grid

Chinese Summary  <27> EGCG作为治疗剂:纳米载体策略最新进展与挑战的系统综述

Chee Ning WONG1, Yang Mooi LIM1, Kai Bin LIEW2, Yik-Ling CHEW3, Ang-Lim CHUA4, Siew-Keah LEE1
1M. Kandiah Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, 43000 Kajang, Selangor, Malaysia
2Faculty of Pharmacy, University of Cyberjaya, 63000 Cyberjaya, Selangor, Malaysia
3Faculty of Pharmaceutical Sciences, UCSI University, 56000 Kuala Lumpur, Malaysia
4Faculty of Medicine, Universiti Teknologi MARA, 47000 Sungai Buloh, Selangor, Malaysia
摘要:表没食子儿茶素-3-没食子酸酯(EGCG)作为绿茶中富含的生物活性多酚,因其具有广泛的治疗应用而备受关注,包括抗氧化、抗炎作用以及潜在的抗癌特性。尽管前景广阔,但EGCG作为药物的实际应用一直受限于其固有的缺陷,包括生物利用度低、不稳定性和易降解等问题。本综述全面探讨了EGCG应用中当前存在的挑战,并评估了基于纳米颗粒的制剂在解决这些限制方面的潜力。凭借独特的理化性质,纳米颗粒为提高EGCG的稳定性、生物利用度和靶向递送提供了平台。目前采用的纳米颗粒策略包括聚合物纳米粒、胶束、脂质纳米载体、金属纳米粒和二氧化硅纳米粒等,这些策略显著增强了EGCG的稳定性与药理活性。本综述指出,大多数纳米载体的粒径分布在300 nm以内,其包封率介于51%至97%之间。值得注意的是,与游离EGCG相比,负载EGCG的纳米颗粒在抗氧化、抗炎、抗癌和抗菌等药理活性方面均有显著提升。通过系统分析现有文献并重点评述最新进展,本文为纳米颗粒介导的EGCG制剂提供了前瞻性见解,为开发更有效且具临床可行性的治疗策略奠定了基础。

关键词组:表没食子儿茶素-3-没食子酸酯(EGCG);纳米颗粒;纳米载体;纳米系统;纳米制剂;稳定性;生物活性


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DOI:

10.1631/jzus.A2400040

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On-line Access:

2025-02-28

Received:

2024-01-21

Revision Accepted:

2024-05-11

Crosschecked:

2025-02-28

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