Abstract: Increasingly, attention is being directed towards time-dependent diffusion magnetic resonance imaging (TDDMRI), a method that reveals time-related changes in the diffusional behavior of water molecules in biological tissues, thereby enabling us to probe related microstructure events. With ongoing improvements in hardware and advanced pulse sequences, significant progress has been made in applying TDDMRI to clinical research. The development of accurate mathematical models and computational methods has bolstered theoretical support for TDDMRI and elevated our understanding of molecular diffusion. In this review, we introduce the concept and basic physics of TDDMRI, and then focus on the measurement strategies and modeling approaches in short- and long-diffusion-time domains. Finally, we discuss the challenges in this field, including the requirement for efficient scanning and data processing technologies, the development of more precise models depicting time-dependent molecular diffusion, and critical clinical applications.

Key words: Time-dependent diffusion; Diffusion magnetic resonance imaging (dMRI); Microstructure imaging; Microstructural model

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