Publishing Service

Polishing & Checking

Journal of Zhejiang University SCIENCE A

ISSN 1673-565X(Print), 1862-1775(Online), Monthly

Dynamic response of the ground beneath a high-speed railway based on typical upper Shanghai clays involving water table change

Abstract: A rising water table increases soil water content, reduces soil strength, and amplifies vibrations under identical train loads, thereby posing greater risks to train operations. To investigate this phenomenon, we used a 2.5D finite element (FE) model of a coupled vehicle‍–‍embankment‍–‍ground system based on Biot’s theory. The ground properties were derived from a typical soil profile of the Yangtze River basin, using geological data from Shanghai, China. The findings indicate that a rise in the water table leads to increased dynamic displacements of both the track and the ground. This amplification effect extends beyond the depth of the water table, impacting the entire embankment‍–‍foundation cross-section, and intensifies with higher train speeds. However, the water table rise has a limited impact on the critical speed of trains and dominant frequency contents. The dynamic response of the embankment is more significantly affected by water table rises within the subgrade than by those within the ground. When the water table rises into the subgrade, significant excess pore pressure is generated inside the embankment, causing a substantial drop in effective stress. As a result, the stress path of the soil elements in the subgrade approaches the Mohr-Coulomb failure line, increasing the likelihood of soil failure.

Key words: Dynamic response; Excess pore pressures; Water table rise; High-speed train; 2.5D finite element (FE) model

Chinese Summary  <13> 住院COVID-19患者循环中ACE2、TLR4和IL-17基因表达与疾病严重程度及预后的潜在关系

Marwa A. DAHPY1,2, Ragaa H. SALAMA1, Abdel-Raheim M. A. MEKI1,3, Ashraf Zein El-ABEDEEN4, Maiada K. HASHEM4, Ebtsam S. ABDULKAREEM5, Mohamed MOHANY6, Sinisa DJURASEVIC7, Amal N. IBRAHIM8, Nourhan M. HUSSEIN8, Shima Gafar MANSOR9, Mohamed Ramadan IZZALDIN10, Marwa K. KHAIRALLAH11, Suzan Eid Elshishtawy IBRAHIM12, Alzahra ABDELBADEA13, Islam Khaled Ali HARBY14, Fatma Y. A. ABBAS15, Rasha M. ALI15, Marwa A. SABET16, Salwa Seif ElDIN17, Abdelraouf M. S. ABDELRAOUF18, Amira A. KAMEL1
1Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
2Department of Medical Biochemistry and Molecular Biology, Armed Forces College of Medicine (AFCM), Cairo 1174, Egypt
3Biochemistry Department, Faculty of Pharmacy, Sphinx University, New Assiut 71515, Egypt
4Department of Chest Diseases, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
5Chest Department, Faculty of Medicine, Aswan University, Aswan 81528, Egypt
6Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
7Faculty of Biology, University of Belgrade, Belgrade 11000, Serbia
8Department of Biochemistry, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt
9Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut 71515, Egypt
10Clinical Pathology, Faculty of Medicine, Al-Azhar University in Assiut, Assiut 71524, Egypt
11Department of Internal Medicine, Faculty of Medicine, Assiut University, Asyut 71515, Egypt
12Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo 11591, Egypt
13Medical Biochemistry and Molecular Biology, Faculty of Medicine for Girls, Al-Azhar University, Cairo 11651, Egypt
14Microbiology & Immunology Department, Faculty of Medicine, Ain Shams University, Cairo 11591, Egypt
15Physiology Department, Faculty of Medicine, Assiut University, Asyut 71515, Egypt
16Department of Microbiology and Immunology, Faculty of Pharmacy, Sphinx University, New Assiut 71684, Egypt
17Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Asyut 71515, Egypt
18Department of Anesthesia and ICU, Faculty of Medicine, Assiut University, Asyut 71515, Egypt
摘要:急性呼吸窘迫综合征(ARDS)是一种进行性低氧血症,可由多种心呼吸系统或全身性疾病(如2019冠状病毒病(COVID-19))引发。严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)病毒刺突蛋白通过与细胞膜上的血管紧张素转化酶2(ACE2)受体结合,介导病毒进入细胞进行复制,并诱导信号级联反应,从而引发促炎反应。这些反应与更高的死亡率和ARDS的进展相关,最终导致患者出现多器官功能衰竭。本研究旨在分析循环中ACE2、Toll样受体4(TLR4)和白细胞介素-17(IL-17)基因表达水平与COVID-19疾病临床严重程度以及住院患者相关病理状况之间的关系。研究纳入了60名COVID-19患者(34名轻/中度和26名重度ARDS)和60名健康对照者。患者组还根据预后进一步细分为32名康复者和28名死亡者。除所有常规基线实验室检查(包括全血细胞计数及分类分析、C-反应蛋白(CRP)、铁蛋白和d-二聚体)外,本研究还通过定量聚合酶链式反应(qPCR)评估了ACE2TLR4IL-17的水平。COVID-19组及其各亚组的ACE2、TLR4和IL-17血清表达水平均显著升高,并与不同的实验室和临床参数相关。ACE2、TLR4和IL-17的血清表达水平在区分患者组与对照组方面表现出良好的准确性,其灵敏度分别为86.7%、91.7%和95.0%,特异性分别为96.7%、98.3%和98.3%,并且与COVID-19患者更严重的病程相关。因此,针对这些生物标志物的研究可能为未来的新冠患者提供额外的治疗选择。

关键词组:急性呼吸窘迫综合征(ARDS);2019冠状病毒病(COVID-19);重症监护室(ICU);血管紧张素转化酶2(ACE2);Toll样受体4(TLR4);白细胞介素-17(IL-17);聚合酶链式反应(PCR)


Share this article to: More

Go to Contents

References:

<Show All>

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





DOI:

10.1631/jzus.A2400345

CLC number:

Download Full Text:

Click Here

Downloaded:

3090

Download summary:

<Click Here> 

Downloaded:

561

Clicked:

2205

Cited:

0

On-line Access:

2025-08-27

Received:

2024-07-16

Revision Accepted:

2024-11-26

Crosschecked:

2025-08-28

Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952276; Fax: +86-571-87952331; E-mail: jzus@zju.edu.cn
Copyright © 2000~ Journal of Zhejiang University-SCIENCE