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Journal of Zhejiang University SCIENCE A
ISSN 1673-565X(Print), 1862-1775(Online), Monthly
2025 Vol.26 No.4 P.285-304
Recent advances in chiral drug separation membranes: design, mechanisms, challenges, and prospects
Abstract: The presence of chirality, a fundamental attribute found in nature, is of great significance in the field of pharmaceutical science. Chiral drugs are unique in that their molecular structure is non-superimposable on its mirror image. This stereoisomerism significantly impacts the functionality, metabolic pathway, effectiveness, and safety of chiral medications. The enantiomers of chiral drugs can exhibit diverse pharmacological effects in the human body. As a result, it is essential to separate and purify chiral drugs effectively. Despite the abundance of reports on chiral drug separation membranes, there is a dearth of comprehensive reviews. This paper aims to fill this gap by providing a thorough review from a materials perspective, with a focus on the design and construction of chiral drug separation membranes. Furthermore, it systematically analyzes the separation mechanisms employed by these membranes. The paper also delves into the challenges and prospects related to chiral drug separation membranes, with the intention of imparting valuable insights for further research and development in this field.
Key words: Chiral drugs; Chiral separation; Separation mechanisms; Membrane separation
机构:1浙江大学绍兴研究院,大健康材料分中心,中国绍兴,312000;2凯里学院,理学院,中国凯里,556011;3浙江大学,高分子合成与功能构造教育部重点实验室,中国杭州,310058;4浙江大学,教育部膜与水处理技术工程研究中心,中国杭州,310058
概要:手性是自然界普遍存在的一种基本性质,在医药科学领域具有重要意义。手性药物的独特之处在于它们的分子结构互为镜像、不可重合,这种立体异构特性对药物的功能、代谢途径、有效性和安全性产生显著影响。手性药物的对映体可在人体内表现出不同的药理作用,通常一种分子具有良好药效,而其对映体没有药效甚至具有毒性。因此,有效分离和纯化手性药物对映体至关重要。虽然近年来关于手性药物分离膜的研究报道日益丰富,但综述类论文较少。本文从材料角度出发,对手性药物分离膜的近期研究进展进行系统梳理,重点介绍膜材料的种类及其制备方法,总结其分离机制,探讨其面临的挑战和未来发展前景,旨在为该领域的进一步研究和新型膜材料开发提供有益参考和借鉴。
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DOI:
10.1631/jzus.A2400409
CLC number:
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On-line Access:
2025-04-30
Received:
2024-08-21
Revision Accepted:
2024-12-17
Crosschecked:
2025-04-30