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Journal of Zhejiang University SCIENCE A

ISSN 1673-565X(Print), 1862-1775(Online), Monthly

Experimental study on vibration source characterization from wheel–rail impacts in urban rapid rail transit turnouts

Abstract: Many railway turnouts are often installed near metro depots and stations, leading to significant environmental vibrations reaching nearby infrastructure. Vibration in turnout zones can originate from various sources, such as rail joints, wheel-load transitions, uneven stiffnesses, rail corrugation, and small-radius curves. These factors contribute to turnout zones having considerably higher vibration levels than plain track sections. Additionally, in urban rapid transit systems, higher train speeds exacerbate wheel–rail impact excitation, further intensifying such vibrations. Despite turnout zones accounting for a large share of environmental vibrations, there have been few systematic studies on their specific sources and mechanisms in the context of rapid transit systems. This knowledge gap has hindered the development and optimization of vibration mitigation strategies for turnout structures. Therefore, in this study, we investigate five representative sets of turnouts from a rapid transit system in a Chinese city, with train speeds ranging from 80 to 150 km/h. Field tests were conducted on real operating trains, with vibration accelerations measured at turnout rails and tunnel walls. This study systematically examines the effects of turnout structure, train carriage position, speed, and vibration mitigation measures on the vibration source characteristics. Time-frequency methods were employed to analyze the test data. Our findings reveal that when train speeds exceed 100 km/h, leading and trailing carriages passing through turnouts induce low-frequency vibrations below 80 Hz, thus generating vibrations in the human-sensitive frequency range. Moreover, train-induced vibrations in turnout zones are primarily concentrated in three frequency bands: 0–20 Hz (associated with structural and stiffness irregularities in the turnouts), 50–80 Hz (P2 resonance of the wheel–rail system), and 150–200 Hz (natural frequencies of the rails).

Key words: Urban rapid rail transit; Railway turnouts; Vibration source characterization; Vibration mitigation; Time-frequency domain analysis; Wheel–rail impact

Chinese Summary  <9> CBR1通过调节细胞干性和静止状态介导非小细胞肺癌化疗敏感性

李伟文1,2,赵嘉璐2,蓝伟红2,叶肖菲2,应可净1
1浙江大学医学院附属邵逸夫医院呼吸与危重症医学科,中国杭州市,310016
2温州医科大学附属第五医院呼吸与危重症医学科,中国丽水市,323000
摘要:羰基还原酶1(CBR1)作为短链脱氢酶/还原酶(SDR)超家族一员,与肿瘤进展和治疗抵抗有关,但其在非小细胞肺癌(NSCLC)中的具体作用尚不明确。本研究检测了CBR1在NSCLC组织和细胞系中的表达,采用基因干扰和药物抑制方法,评估了CBR1对肿瘤干性、化疗敏感性和细胞静止状态的影响,进一步探讨了其潜在机制。研究结果表明,CBR1在NSCLC组织和细胞系中表达升高,且顺铂(CDDP)处理可进一步诱导其表达上调。通过基因干扰下调CBR1表达后,CD133阳性细胞百分比显著降低,OCT4和SOX2的表达下降,同时细胞对CDDP的化疗敏感性增强。CBR1特异性抑制剂hydroxy-PP-Me(PP-Me)显著增加了CDDP的细胞毒性,并抑制了细胞干性。此外,sh-CBR1或PP-Me处理能够有效改变NSCLC细胞的静止状态,具体表现为G0期细胞比例和p27表达下降而cyclin D1和pRb表达上升。进一步研究发现,SETD4作为介导NSCLC细胞干性、化疗敏感性和静止状态的因子,在sh-CBR1或PP-Me处理后表达下调而过表达SETD4则可逆转由CBR1抑制所增强的化疗敏感性。在A549异种移植模型中,PP-Me与CDDP联合治疗的抑瘤效果显著优于单药治疗。综上所述,抑制CBR1可通过阻断肿瘤干性与静止期,增强NSCLC对CDDP的化疗敏感性。

关键词组:羰基还原酶1(CBR1);SET结构域包含蛋白4(SETD4);化疗敏感性;干性;静止状态;非小细胞肺癌(NSCLC)


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DOI:

10.1631/jzus.A2400509

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On-line Access:

2025-11-24

Received:

2024-10-29

Revision Accepted:

2025-03-26

Crosschecked:

2025-11-25

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