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Journal of Zhejiang University SCIENCE B
ISSN 1673-1581(Print), 1862-1783(Online), Monthly
2014 Vol.15 No.3 P.243-255
Estrogen receptor α gene PvuII polymorphism and coronary artery disease: a meta-analysis of 21 studies
Abstract: The association between the estrogen receptor α gene (ESR1) PvuII polymorphism (c.454-397T>C) and coronary artery disease (CAD) is controversial. Thus, we conducted a meta-analysis to evaluate the relationship. Data were collected from 21 studies encompassing 9926 CAD patients and 16710 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the relationship between PvuII polymorphism and CAD. The polymorphism in control populations in all studies followed Hardy-Weinberg equilibrium. We found a significant association between ESR1 PvuII polymorphism and CAD risk in all subjects. When the data were stratified by region, a significant association between ESR1 PvuII polymorphism and CAD risk was observed in Asian populations but not in Western populations. The current study suggests that ESR1 PvuII polymorphism has an important role in CAD susceptibility.
Key words: Estrogen receptor α gene, Polymorphism, Meta-analysis, Coronary artery disease (CAD)
创新要点：目前关于雌激素受体α基因PvuII基因多态性 （c.454-397T>C）与冠心病的关系仍存在争议。因此本研究针对这一问题系统收集国内外符合纳入与排除标准的研究，通过meta分析，系统地评估雌激素受体α基因PvuII 基因多态性与冠心病的关系。
研究方法：针对研究问题系统检索国内外相关数据库，根据事先制定的纳入与排除标准及质量评价量表，筛选出符合标准的研究文献。利用STATA11.0和RevMan 5.2软件对纳入的21篇研究（包括9926病例和16710对照）进行定量分析。优势比（OR）值及95%置信区间（CI）用来衡量雌激素受体α基因PvuII基因多态性与冠心病的关系。
重要结论：Meta分析结果提示，雌激素受体α基因ESR1 PvuII基因多态性与冠心病的关系在研究的整体人群中有重要意义。地区亚组分析显示，在亚洲人群中，雌激素受体α基因PvuII基因多态性与冠心病相关，然而这种相关性不存在于西方人群。
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DOI:
10.1631/jzus.B1300220
CLC number:
R541.4
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On-line Access:
2014-03-04
Received:
2013-08-20
Revision Accepted:
2013-11-17
Crosschecked:
2014-02-19