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Journal of Zhejiang University SCIENCE B

ISSN 1673-1581(Print), 1862-1783(Online), Monthly

Hypoxia-inducible factor 1 and breast cancer metastasis

Abstract: Accumulating evidence has shown that the hypoxic microenvironment, which is critical during cancer development, plays a key role in regulating breast cancer progression and metastasis. The effects of hypoxia-inducible factor 1 (HIF-1), a master regulator of the hypoxic response, have been extensively studied during these processes. In this review, we focus on the roles of HIF-1 in regulating breast cancer cell metastasis, specifically its effects on multiple key steps of metastasis, such as epithelial-mesenchymal transition (EMT), invasion, extravasation, and metastatic niche formation. We also discuss the roles of HIF-1-regulated non-coding RNAs in breast cancer metastasis, and therapeutic opportunities for breast cancer through targeting the HIF-1 pathway.

Key words: Breast cancer, Hypoxia-inducible factor 1 (HIF-1), Metastasis

Chinese Summary  <41> 低氧诱导因子与乳腺癌转移

概要:肿瘤,特别是实体瘤,其内部微环境处于一种低氧或缺氧的状态,肿瘤的这种低氧微环境将诱导活化低氧诱导因子(HIF-1)信号通路。HIF-1信号通路在乳腺癌的转移中发挥着重要的作用。乳腺癌的转移涉及肿瘤细胞的浸润、进入血管、通过血液循环迁移、到达远端毛细血管内壁、穿透血管壁进入新的器官以及在新的部位形成转移灶等步骤,过程非常复杂。本文重点围绕HIF-1在转移各个步骤中的作用进行综述。

关键词组:乳腺癌;低氧诱导因子;肿瘤转移


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DOI:

10.1631/jzus.B1400221

CLC number:

R737.9; Q2

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On-line Access:

2024-08-27

Received:

2023-10-17

Revision Accepted:

2024-05-08

Crosschecked:

2014-12-18

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