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Journal of Zhejiang University SCIENCE B
ISSN 1673-1581(Print), 1862-1783(Online), Monthly
2017 Vol.18 No.1 P.76-78
Inhibitory effect of Shenqi Fuzheng injection combined with docetaxel on lung cancer cells
Abstract: This study investigated the anticancer effect of Shenqi Fuzheng (SQFZ) injection combined with docetaxel on lung cancer cell lines of A549 and Lewis lung cancer (LLC). SQFZ injection alone cannot inhibit the vitality of lung cancer cells, but the antitumor activity of SQFZ combined with docetaxel was significantly higher than that using docetaxel alone.
Key words: Shenqi Fuzheng injection, Docetaxel, Lung cancer cell, Inhibition ratio
创新点：首次发现参芪扶正注射液配伍多西他赛后能提高低浓度多西他赛对肺癌细胞的生长抑制率，且对不同肺癌细胞的抑制率有不同的增强作用。
方法：对A549及LLC细胞均设置参芪扶正注射液五个浓度单独给药、多西他赛九个浓度单独给药、参芪扶正注射液两个浓度分别联合多西他赛五个浓度给药三组。使用MTT比色法考察不同给药组对于肺癌细胞的生长抑制率，并对比多西他赛单独与联用后对细胞生长的抑制率。
结论：实验结果显示参芪扶正注射液单独使用对于两种肺癌细胞均无明显抑制作用，但是联合使用对多西他赛抗肿瘤作用有明显的增强效果。
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DOI:
10.1631/jzus.B1600357
CLC number:
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On-line Access:
2017-01-03
Received:
2016-08-10
Revision Accepted:
2016-11-09
Crosschecked:
2016-12-16