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Journal of Zhejiang University SCIENCE B

ISSN 1673-1581(Print), 1862-1783(Online), Monthly

2017 Vol.18 No.8 P.727-732

Network analysis identifies common genes associated with obesity in six obesity-related diseases

Li-ning Su, Yan-bing Wang, Chun-guang Wnag, Hui-ping Wei

Department of Biology, Hebei North University, Zhangjiakou 075029, China; Department of Public Sports, Hebei North University, Zhangjiakou 075029, China; Department of Cardiac Function Examination, the First Affiliated Hospital, Hebei North University, Zhangjiakou 075061, China

whp123456@sina.com

Abstract: Obesity has been reported to be associated with many diseases. However, common obesity-induced biological processes have not been evaluated across these diseases. We identified genes associated with obesity and obesity-related diseases, and used them to construct protein‒protein interaction networks. We also analyzed gene ontology (GO) in those genes overlapping between obesity and disease. Our work identifies gene modules common to obesity and obesity-related diseases, which can provide a basis for understanding the process of how obesity induces disease.

Key words: Obesity; Obesity-related diseases; CAD; Diabetes; Hypertension; Breast cancer; Polycystic ovarian syndrome; Kidney cancer

Chinese Summary  <19> 网络分析筛选六种与肥胖相关疾病的共同的肥胖基因

目的：通过筛选在六种与肥胖相关疾病中发挥作用的共同的肥胖基因，阐明肥胖在疾病发生及发展中的作用，为预防及治疗肥胖相关的一系列疾病提供参考。
创新点：首次分析了与肥胖相关疾病的共同的肥胖基因，为解释肥胖与疾病的关系提供理论支持。
方法：从疾病及肥胖数据库中获得与疾病和肥胖相关的基因，利用生物信息学软件进行蛋白互作网络分析和中心基因分析，筛选中心基因；对疾病与肥胖数据库中的重叠基因进行GO（Gene Ontology,基因本体）功能富集，获得在疾病中发挥作用的共同的基因本体功能集群。
结论：通过分析初步推测六种与肥胖相关疾病中的31个中心基因中包括17个肥胖基因，每种疾病与肥胖的重叠基因具有一些相同的基因本体功能集群。

关键词组：肥胖；肥胖相关疾病；冠状动脉疾病；高血压；糖尿病；乳腺癌；肾癌；多囊综合症


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DOI:

10.1631/jzus.B1600454

CLC number:

R589.2

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On-line Access:

2017-08-08

Received:

2016-10-08

Revision Accepted:

2017-03-14

Crosschecked:

2017-07-19

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