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Journal of Zhejiang University SCIENCE B

ISSN 1673-1581(Print), 1862-1783(Online), Monthly

2019 Vol.20 No.6 P.488-495

Exosomal long non-coding RNAs: biological properties and therapeutic potential in cancer treatment

Jie Luo, Yan Xiong, Pei-Fen Fu, En-Chun Li, Lei Qu, Xiao Fan, Zhi-Jian Cai, Ai-Fu Lin

Department of Gynecology, Womens Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China; Department of Orthopedic Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; The Breast Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; MOE Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences, Zhejiang University, Hangzhou 310058, China; Institute of Immunology, and Department of Orthopaedics, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China

linaifu@zju.edu.cn, caizj@zju.edu.cn

Abstract: Exosomes and long non-coding RNAs (lncRNAs) are emerging as important elements contributing to a more comprehensive understanding of cancer development and progression. The discovery of lncRNAs in exosomes further indicates their bona fide biological functional roles in cancer development and drug resistance. In this review, we describe the biogenesis of exosomes and summarize the function of exosomal lncRNAs in the field of cancer research. These findings strikingly advance current knowledge of exosomal lncRNAs and suggest that they may be promising diagnostic biomarkers and therapeutic targets for cancer.

Key words: Exosome; Long non-coding RNA (lncRNA); Biosynthesis; Biomarker; Drug resistance

Chinese Summary  <29> 外泌体lncRNA研究进展及其肿瘤靶向潜质

关键词组：外泌体;长链非编码RNA(lncRNA);生物合成;生物标志物;肿瘤靶点;临床耐药


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DOI:

10.1631/jzus.B1900039

CLC number:

Q39

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On-line Access:

2024-08-27

Received:

2023-10-17

Revision Accepted:

2024-05-08

Crosschecked:

2019-05-03

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