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Journal of Zhejiang University SCIENCE B

ISSN 1673-1581(Print), 1862-1783(Online), Monthly

2020 Vol.21 No.2 P.166-171

CX3CR1 contributes to streptozotocin-induced mechanical allodynia in the mouse spinal cord

Cheng-ming Ni, Bing-yu Ling, Xiang Xu, He-ping Sun, Hui Jin, Yu-qiu Zhang, Hong Cao, Lan Xu

Department of Endocrinology, the Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi 214023, China; Department of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China; Department of Emergency, Northern Jiangsu People’s Hospital, Yangzhou University, Yangzhou 225001, China; Department of Endocrinology, the Affiliated Kunshan First People’s Hospital of Jiangsu University, Kunshan 215300, China

hongcao@fudan.edu.cn, xulan126@126.com

Abstract: Patients with diabetic peripheral neuropathy experience debilitating pain that significantly affects their quality of life (Abbott et al., 2011), by causing sleeping disorders, anxiety, and depression (Dermanovic Dobrota et al., 2014). The primary clinical manifestation of painful diabetic neuropathy (PDN) is mechanical hypersensitivity, also known as mechanical allodynia (MA) (Callaghan et al., 2012). MA’s underlying mechanism remains poorly understood, and so far, based on symptomatic treatment, it has no effective therapy (Moore et al., 2014).

Key words: FKN/CX3CR1; Mechanical allodynia; STZ-induced diabetic mice

Chinese Summary  <28> CX3CL1受体参与1型糖尿病机械痛的形成

关键词组：趋化因子(CX3CL1);趋化因子受体(CX3CR1);机械痛;链脲佐菌素;糖尿病模型


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DOI:

10.1631/jzus.B1900439

CLC number:

R587.2

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On-line Access:

2024-08-27

Received:

2023-10-17

Revision Accepted:

2024-05-08

Crosschecked:

2020-02-04

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