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Journal of Zhejiang University SCIENCE B

ISSN 1673-1581(Print), 1862-1783(Online), Monthly

Transmission risk of patients with COVID-19 meeting discharge criteria should be interpreted with caution

Abstract: As of Apr. 22, 2020, the World Health Organization (2020) has reported over 2.4 million confirmed coronavirus disease 2019 (COVID-19) patients and 169 151 deaths. Recent articles have uncovered genomic characteristics and clinical features of COVID-19 (Chan et al., 2020; Chang et al., 2020; Guan et al., 2020; Zhu et al., 2020), while our understanding of COVID-19 is still limited. As suggested by guidelines promoted by the General Office of National Health Commission of the People’s Republic of China (2020) (from Versions 1 to 6), discharged standards for COVID-19 were still dependent on viral real-time polymerase chain reaction (RT-PCR) tests of respiratory specimens, showing that recovered COVID-19 patients with twice negative RT-PCR could meet discharge criteria. Here, we examined two cases in which nucleic acid test results were inconsistent with clinical and radiological findings, leading to suboptimal care.

Key words: Coronavirus disease 2019 (COVID-19); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Real-time polymerase chain reaction (RT-PCR)

Chinese Summary  <23> 需谨慎考虑符合出院标准的2019冠状病毒病患者的传染性

关键词组:2019冠状病毒病(COVID-19);新型冠状病毒(SARS-CoV-2);实时聚合酶链式反应(RT-PCR)


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DOI:

10.1631/jzus.B2000117

CLC number:

R511

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On-line Access:

2020-05-19

Received:

2020-03-12

Revision Accepted:

2020-04-12

Crosschecked:

2020-05-08

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