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Journal of Zhejiang University SCIENCE B
ISSN 1673-1581(Print), 1862-1783(Online), Monthly
2022 Vol.23 No.9 P.705-731
Biomarkers in oral immunotherapy
Abstract: Food allergy (FA) is a global health problem that affects a large population, and thus effective treatment is highly desirable. Oral immunotherapy (OIT) has been showing reasonable efficacy and favorable safety in most FA subjects. Dependable biomarkers are needed for treatment assessment and outcome prediction during OIT. Several immunological indicators have been used as biomarkers in OIT, such as skin prick tests, basophil and mast cell reactivity, T cell and B cell responses, allergen-specific antibody levels, and cytokines. Other novel indicators also could be potential biomarkers. In this review, we discuss and assess the application of various immunological indicators as biomarkers for OIT.
Key words: Food allergy; Oral immunotherapy; Biomarker; Immune tolerance; Desensitization
机构：1浙江大学，建筑工程学院，岩土工程研究所，中国杭州，310058；2香港理工大学，土木与环境工程系，中国香港，九龙红磡；3忠北国立大学，土木工程学院，韩国忠北清州市，28644
目的：研究润湿性对于多孔介质驱替的影响，以提高驱替效率。
创新点：1.同时考虑了润湿性、毛细管数和粘滞比三者对驱替的影响并建立了三维相图；2.采用可以准确模拟接触角的边界条件算法，且模拟范围包含所有润湿性条件。
方法：采用格子波尔兹曼方法（LBM）对不同毛细管数-粘滞比组合下的19组接触角进行模拟，建立其与驱替形态和效率的影响。
结论：1.存在最优接触角使得击穿时的驱替效率最高；2.三维驱替相图包含了传统相图，反映了润湿性会使二维相图的驱替区域整体偏移。
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DOI:
10.1631/jzus.B2200047
CLC number:
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On-line Access:
2022-06-16
Received:
2022-01-26
Revision Accepted:
2022-05-10
Crosschecked:
2022-09-16