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Journal of Zhejiang University SCIENCE B

ISSN 1673-1581(Print), 1862-1783(Online), Monthly

2022 Vol.23 No.10 P.844-862

Iron metabolism, ferroptosis, and lncRNA in cancer: knowns and unknowns

Lei QU, Xinyu HE, Qian TANG, Xiao FAN, Jian LIU, Aifu LIN

MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou 310058, China; Cancer Center, Zhejiang University, Hangzhou 310058, China; Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Hangzhou 310058, China; Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining 314400, China; Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People’s Hospital, Cancer Center, Zhejiang University School of Medicine, Hangzhou 310006, China; College of Medicine and Veterinary Medicine, the University of Edinburgh, Edinburgh EH16 4SB, UK; Biomedical and Health Translational Research Center of Zhejiang Province, Haining 314400, China; Breast Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; International School of Medicine, International Institutes of Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, China; ZJU-QILU Joint Research Institute, Hangzhou 310058, China

jianl@intl.zju.edu.cn, linaifu@zju.edu.cn

Abstract: Cancer cells undergo substantial metabolic alterations to sustain increased energy supply and uncontrolled proliferation. As an essential trace element, iron is vital for many biological processes. Evidence has revealed that cancer cells deploy various mechanisms to elevate the cellular iron concentration to accelerate proliferation. Ferroptosis, a form of cell death caused by iron-catalyzed excessive peroxidation of polyunsaturated fatty acids (PUFAs), is a promising therapeutic target for therapy-resistant cancers. Previous studies have reported that long noncoding RNA (lncRNA) is a group of critical regulators involved in modulating cell metabolism, proliferation, apoptosis, and ferroptosis. In this review, we summarize the associations among iron metabolism, ferroptosis, and ferroptosis-related lncRNA in tumorigenesis. This information will help deepen understanding of the role of lncRNA in iron metabolism and raise the possibility of targeting lncRNA and ferroptosis in cancer combination therapy.

Key words: Iron metabolism; Ferroptosis; Long noncoding RNA (lncRNA); Tumorigenesis

Chinese Summary  <43> 癌症中的铁代谢、铁死亡和长链非编码RNA：已知与未知

瞿蕾1,2,3，何欣豫1,2,3，唐倩4,5,6,7，樊晓1,2,3，刘坚4,5,6,7，林爱福1,2,3,8,9,10
1浙江大学生命科学学院生物系统稳态与保护教育部实验室，中国杭州市，310058
2浙江大学癌症研究中心，中国杭州市，310058
3浙江省细胞与基因工程重点实验室，中国杭州市，310058
4浙江大学医学院浙江大学爱丁堡大学联合学院，中国海宁市，314400
5浙江省临床肿瘤药理与毒品理学研究重点实验室，浙江大学医学院附属杭州市第一人民医院，浙江大学癌症研究院，中国杭州市，310006
6爱丁堡大学医学院和兽医学院，英国爱丁堡，EH16 4SB
7浙江省生物医学与工程转化国际科技合作基地，中国海宁市，314400
8浙江大学医学院附属第一医院乳腺疾病诊治中心，中国杭州市，310003
9浙江大学医学院第四附属医院国际医学院，中国义乌市，322000
10浙江大学-齐鲁制药联合研究院，中国杭州市，310058
概要：代谢重编程是肿瘤标志性事件之一，癌细胞通过代谢重编程满足自身能量供应以及无限增殖。铁作为生命必要微量元素之一，对多种生物学过程包括DNA合成和修复、细胞呼吸、氧气运输、脂质氧化、信号转导等过程至关重要。研究表明，癌细胞通过多种机制增加细胞内铁离子浓度以促进细胞增殖。铁死亡是一种由铁催化的多不饱和脂肪酸过氧化引起的细胞死亡形式，是治疗耐药性肿瘤的潜在治疗靶点。长链非编码RNA（lncRNA）作为一种新型调控元件参与调节细胞代谢、增殖、凋亡和铁死亡等多种细胞过程。在本综述中，我们总结了铁代谢、铁死亡和lncRNA在肿瘤发生中的关系。深入探讨lncRNA在肿瘤铁死亡中的作用，将为联合靶向lncRNA和铁死亡相关分子在肿瘤治疗中提供新的策略和视角。

关键词组：铁代谢；铁死亡；长链非编码RNA（lncRNA）；肿瘤发生


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DOI:

10.1631/jzus.B2200194

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On-line Access:

2024-08-27

Received:

2023-10-17

Revision Accepted:

2024-05-08

Crosschecked:

2022-10-13

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