Publishing Service

Polishing & Checking

Journal of Zhejiang University SCIENCE B

ISSN 1673-1581(Print), 1862-1783(Online), Monthly

Chinese consensus guidelines for therapeutic drug monitoring of polymyxin B, endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society

Abstract: Polymyxin B, which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections, became available in China in Dec. 2017. As dose adjustments are based solely on clinical experience of risk toxicity, treatment failure, and emergence of resistance, there is an urgent clinical need to perform therapeutic drug monitoring (TDM) to optimize the use of polymyxin B. It is thus necessary to standardize operating procedures to ensure the accuracy of TDM and provide evidence for their rational use. We report a consensus on TDM guidelines for polymyxin B, as endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society. The consensus panel was composed of clinicians, pharmacists, and microbiologists from different provinces in China and Australia who made recommendations regarding target concentrations, sample collection, reporting, and explanation of TDM results. The guidelines provide the first-ever consensus on conducting TDM of polymyxin B, and are intended to guide optimal clinical use.

Key words: Polymyxin B; Therapeutic drug monitoring (TDM); Pharmacokinetics; Clinical efficacy

Chinese Summary  <216> DDUC:数据更新与编码解耦的纠删码系统

屠要峰1,2,肖蓉2,韩银俊1,2,陈正华2,金浩2,齐学成2,孙辛远2
1移动网络和移动多媒体技术国家重点实验室,中国深圳市,518000
2中兴通讯股份有限公司,中国南京市,210000
摘要:在分布式存储系统中,常用的数据冗余方法包括副本和纠删码(erasure code,EC)。相较于副本,EC具有更好的存储效率,但是在更新方面的开销更大。此外,并发更新带来的一致性和可靠性问题给EC应用带来了新的挑战。许多研究工作都致力于优化EC技术,包括算法优化、数据更新方法创新等,但并发更新的一致性和可靠性问题尚未得到很好解决。本文介绍了一种将数据更新与EC编码解耦的存储系统,命名为DDUC,并提出了一种副本与校验块结合的放置策略。对于(N, M)的EC系统,按照NM+1的副本进行数据布局,并将同一条带的冗余数据块都放置在校验节点上,使得校验节点可以自主地执行本地EC编码。基于上述策略,实现了一种两阶段数据更新方法,在第一阶段按照副本模式进行数据更新,在第二阶段由校验节点独立完成EC编码。这样在保证高并发性能的同时,解决了并发更新导致的数据可靠性降低的问题。同时利用PMem硬件的字节寻址和8字节原子写特性实现了一种轻量级的日志机制,在提升性能的同时保证了数据的一致性。实验结果表明,和当前主流的存储系统Ceph相比,本文所提出的存储系统并发访问性能提升至1.70-3.73倍,时延仅为Ceph的3.4%-5.9%。

关键词组:并发更新;高可靠性;纠删码;一致性;分布式存储系统


Share this article to: More

Go to Contents

References:

<Show All>

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





DOI:

10.1631/jzus.B2200466

CLC number:

Download Full Text:

Click Here

Downloaded:

2255

Download summary:

<Click Here> 

Downloaded:

738

Clicked:

5143

Cited:

0

On-line Access:

2024-08-27

Received:

2023-10-17

Revision Accepted:

2024-05-08

Crosschecked:

2023-02-09

Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952276; Fax: +86-571-87952331; E-mail: jzus@zju.edu.cn
Copyright © 2000~ Journal of Zhejiang University-SCIENCE