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Journal of Zhejiang University SCIENCE B
ISSN 1673-1581(Print), 1862-1783(Online), Monthly
2023 Vol.24 No.12 P.1141-1150
A case of vitiligo after COVID-19 vaccination: a possible role of thymic dysfunction
Abstract: During the coronavirus disease 2019 (COVID-19) pandemic, vaccines help control the spread of infection. To date, 47 vaccines have been approved, with another 227 candidates in various stages of development. In the short period of time since the beginning of their use, evidence has begun to emerge of complications following vaccination in the form of the development or exacerbation of a number of pathological conditions (Block et al., 2022; Haseeb et al., 2022). For example, a population-based study in France identified 1612 cases of myocarditis and 1613 cases of pericarditis requiring hospital treatment within five months of vaccination (le Vu et al., 2022).
Key words: vitiligo, COVID-19 vaccination, thymic dysfunction, autoimmunity, сomplication, stress
1G.N. Gabrichevsky Scientific and Research Institute of Epidemiology and Microbiology, Moscow 125212, Russia
2I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia
3Perm State Pharmaceutical Academy, Perm 614990, Russia
摘要：最近，人们发现接种2019冠状病毒病（COVID-19）疫苗后出现了大量并发症，影响心脏、肾脏、胰腺、关节和皮肤。本文结合已报道的11例COVID-19疫苗（主要与信使RNA（mRNA）疫苗有关）接种后白癜风病例的数据和我们自己接种的1例非复制载体疫苗后的白癜风病例，分析探讨了其相关的病理机制。根据常见的原理，自身免疫性病变是通过病毒的抗原表位与某些人类蛋白质之间的分子模拟诱发的。我们认为这一过程的基础是胸腺负选择的破坏，导致自身反应性T细胞迁移到外周。在本文中，我们证实了疫苗和/或感染以及黑素细胞氧化应激是自身免疫反应的主要诱因。在这种情况下，白癜风的发病机制可被视为糖尿病或动脉粥样硬化等多种自身免疫性疾病发病机制的模型。此外，我们概述了一种病理机制，其中黑色素细胞氧化应激、自身反应性T细胞和胸腺功能障碍可作为干预策略的潜在目标。
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DOI:
10.1631/jzus.B2300025
CLC number:
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On-line Access:
2024-08-27
Received:
2023-10-17
Revision Accepted:
2024-05-08
Crosschecked:
2023-12-12