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Journal of Zhejiang University SCIENCE B
ISSN 1673-1581(Print), 1862-1783(Online), Monthly
2024 Vol.25 No.10 P.841-856
Neural substrates for regulating self-grooming behavior in rodents
Abstract: Grooming, as an evolutionarily conserved repetitive behavior, is common in various animals, including humans, and serves essential functions including, but not limited to, hygiene maintenance, thermoregulation, de-arousal, stress reduction, and social behaviors. In rodents, grooming involves a patterned and sequenced structure, known as the syntactic chain with four phases that comprise repeated stereotyped movements happening in a cephalocaudal progression style, beginning from the nose to the face, to the head, and finally ending with body licking. The context-dependent occurrence of grooming behavior indicates its adaptive significance. This review briefly summarizes the neural substrates responsible for rodent grooming behavior and explores its relevance in rodent models of neuropsychiatric disorders and neurodegenerative diseases with aberrant grooming phenotypes. We further emphasize the utility of rodent grooming as a reliable measure of repetitive behavior in neuropsychiatric models, holding promise for translational psychiatry. Herein, we mainly focus on rodent self-grooming. Allogrooming (grooming being applied on one animal by its conspecifics via licking or carefully nibbling) and heterogrooming (a form of grooming behavior directing towards another animal, which occurs in other contexts, such as maternal, sexual, aggressive, or social behaviors) are not covered due to space constraints.
Key words: Grooming; Repetitive behavior; Syntactic chain; Cephalocaudal progression; Neuropsychiatric disorders
1中国科学院动物研究所，农业虫害鼠害综合治理研究国家重点实验室，中国北京市，100101
2中国科学院大学，中国科学院生物互作卓越创新中心，中国北京市，100101
3河北大学生命科学学院，中国保定市，071002
4中国科学院遗传与发育生物学研究所，分子发育生物学国家重点实验室，中国北京市，100101
5天津市环湖医院康复医学科，中国天津市，300350
6首都医科大学附属北京朝阳医院人类生殖医学中心，中国北京市，100101
7招远市人民医院胃肠外科，中国招远市，265400
8中国科技大学生命科学与医学学院，中国合肥市，230026
9复旦大学附属眼耳鼻喉科医院耳鼻喉科，中国上海市，200031
10复旦大学附属眼耳鼻喉科医院耳鼻喉科研究院，中国上海市，200031
11复旦大学附属眼耳鼻喉科医院嗅觉疾病诊疗及研究中心，中国上海市，200031
摘要：梳理是一种进化上保守的刻板行为，广泛存在于包括人类在内的各种动物中。梳理行为在动物维持体表清洁、调节体温、去觉醒、减轻压力以及社会行为等方面发挥重要功能。在啮齿类动物中，梳理行为通常可以分为四个连续的阶段，并以从头至尾顺序的方式进行重复刻板动作：从口鼻部到面部，到头部，最后以舔舐躯体结束。梳理行为的发生具有环境依赖性，说明此行为具有适应的重要性。本综述简要总结了啮齿类动物梳理行为涉及的神经基质，并探讨了异常梳理行为表型的存在与神经精神疾病和神经退行性疾病模型的相关性。此外，本文进一步强调指出，在神经精神病学模型中，啮齿类动物的梳理行为可作为测定重复刻板行为的一种可靠测量方法，有望在转化精神病学中应用。本文主要聚焦啮齿动物的自我理毛行为，因受限于篇幅，未对allogrooming（同种动物通过舔舐或以仔细啃咬的方式为另一种动物梳理毛发）与heterogrooming（在特定情况下发生的对另一种动物的梳理行为，如母性行为、性行为、攻击行为或社会行为）展开讨论。
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DOI:
10.1631/jzus.B2300562
CLC number:
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On-line Access:
2024-08-27
Received:
2023-10-17
Revision Accepted:
2024-05-08
Crosschecked:
2024-10-18