JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

ISSN 1673-1581(Print), 1862-1783(Online), Monthly

2024 Vol.25 No.2 P.168-180

A proton birdcage coil integrated with interchangeable single loops for multi-nuclear MRI/MRS

Yi ZHANG, Zhiyan QUAN, Feiyang LOU, Yujiao FANG, Garth J. THOMPSON, Gao CHEN, Xiaotong ZHANG

Department of Neurosurgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University,Hangzhou310009,China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases,Hangzhou310009,China; MOE Frontier Science Center for Brain Science and Brain-machine Integration, Zhejiang University,Hangzhou310058,China; Interdisciplinary Institute of Neuroscience and Technology, College of Biomedical Engineering & Instrument Science, Zhejiang University,Hangzhou310027,China; School of Medicine, Zhejiang University,Hangzhou310020,China; iHuman Institute, School of Life Science and Technology, ShanghaiTech University,Shanghai201210,China; College of Electrical Engineering, Zhejiang University,Hangzhou310027,China

d-chengao@zju.edu.cn, zhangxiaotong@zju.edu.cn

Abstract: Energy metabolism is fundamental for life. It encompasses the utilization of carbohydrates, lipids, and proteins for internal processes, while aberrant energy metabolism is implicated in many diseases. In the present study, using three-dimensional (3D) printing from polycarbonate via fused deposition modeling, we propose a multi-nuclear radiofrequency (RF) coil design with integrated¹H birdcage and interchangeable X-nuclei (²H,¹³C,²³Na, and³¹P) single-loop coils for magnetic resonance imaging (MRI)/magnetic resonance spectroscopy (MRS). The single-loop coil for each nucleus attaches to an arc bracket that slides unrestrictedly along the birdcage coil inner surface, enabling convenient switching among various nuclei and animal handling. Compared to a commercial¹H birdcage coil, the proposed¹H birdcage coil exhibited superior signal-excitation homogeneity and imaging signal-to-noise ratio (SNR). For X-nuclei study, prominent peaks in spectroscopy for phantom solutions showed excellent SNR, and the static and dynamic peaks of in vivo spectroscopy validated the efficacy of the coil design in structural imaging and energy metabolism detection simultaneously.

Key words: Energy metabolism; Magnetic resonance imaging (MRI); Magnetic resonance spectroscopy (MRS); Multi-nuclear; Radiofrequency coil; Three-dimensional (3D) printing

Chinese Summary <15> 一种用于多核磁共振成像及波谱的鸟笼线圈与可更换单环线圈的一体化设计

张怡^1,2,3，全枝艳^3,4，楼飞洋^3,4,5，方玉娇⁶，Garth J. THOMPSON⁶，陈高^1,2，张孝通^1,2,3,4,5,7
¹浙江大学医学院附属第二医院神经外科，中国杭州市，310009
²浙江省神经外科疾病精准诊治及临床转化重点实验室，中国杭州市，310009
³浙江大学教育部脑与脑机融合前沿科学中心，中国杭州市，310058
⁴浙江大学系统神经与认知科学研究所，中国杭州市，310027
⁵浙江大学医学院，中国杭州市，310020
⁶上海科技大学iHuman研究所，中国上海市，201210
⁷浙江大学电气工程学院，中国杭州市，310027
摘要：能量代谢对生命活动至关重要，主要包括对碳水化合物、脂肪和蛋白质的利用过程，异常的能量代谢与诸多疾病密切相关。本研究提出了一种用于多核磁共振成像（MRI）与波谱（MRS）的射频线圈设计：通过3D打印线圈外壳和支架，将一个鸟笼¹H线圈和可更换的单环X核（²H、¹³C、²³Na和³¹P）线圈一体化集成，其中单环线圈通过一个弧形支架安装于鸟笼线圈内壁，使其可沿内壁轴向无阻碍地移动，方便实现成像实验中多核线圈的更换以及线圈相对于不同成像体的摆放。与商用鸟笼¹H核线圈相比，本设计具有更好的¹H信号激发均匀性和成像信噪比；小鼠的活体实验验证了线圈设计在成像与波谱研究方面的可行性与有效性，可同时满足结构成像和能量代谢检测的要求。综上所述，该多核线圈通过新型机械与电路设计可以简化多核磁共振成像能量代谢检测的实施过程。

关键词组：能量代谢；核磁共振成像；磁共振波谱；多核；射频线圈；3D打印

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DOI:

10.1631/jzus.B2300587

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2024-08-27

Received:

2023-10-17

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2024-05-08

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2024-02-02

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