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Journal of Zhejiang University SCIENCE B
ISSN 1673-1581(Print), 1862-1783(Online), Monthly
2025 Vol.26 No.2 P.200-202
Application of custom-made joint prostheses in wrist
Abstract: The wrist joint is a highly mobile functional joint. Wrist conditions including traumatic and degenerative arthritis, rheumatoid arthritis, and giant cell tumors of the distal radius, cause significant pain and mobility impairment. In joint surgery, the decision to use joint prostheses to reconstruct joint function is greatly influenced by the characteristics of the prosthesis (Mok et al., 2016). However, traditional implants have limitations such as shape mismatch, inadequate implant–bone interface strength which causes loosening, and poor bone ingrowth (Zhang et al., 2014).
Key words: Polycomb repressive complexes (PRC); CBX proteins; Epigenetic regulation; Cancer
1浙江大学医学院附属第一医院骨科，中国杭州市，310003
2浙江中医药大学附属第二医院（浙江省新华医院）骨科，中国杭州市，310014
摘要：手腕关节是高度活动的功能性关节，各种创伤和退行性疾病均可导致严重的疼痛和活动受限。关节置换术是重建关节功能的主要治疗方式，但传统假体存在诸如形状不匹配、植入物-骨界面强度不足导致松动以及骨内生长欠佳等缺陷。三维（3D）打印技术的应用为解决这些问题提供了新的解决方案，能实现更加个性化的设计，并改善假体与骨骼的契合度。本文回顾了手腕关节假体的发展历程，从最早的Swanson假体到当前广泛使用的第四代假体，分析了各代假体的设计特点及临床应用情况。研究发现，相比传统定制假体，3D打印假体在缓解疼痛和恢复关节功能等方面表现更优。但目前关于3D打印假体的长期临床随访数据仍有限，需进一步评估其长期疗效及并发症。此外，金属假体存在的腐蚀问题也是亟待解决的挑战，未来需要通过探索新的生物材料和表面处理技术以提高假体的生物相容性和抗菌性。3D打印技术为手腕关节假体的个性化设计和性能提升带来了新的契机，有望为患者提供更优质的治疗选择。但现有研究仍有待深化，还需在长期临床疗效和新材料开发等方面进一步推进。
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DOI:
10.1631/jzus.B2400102
CLC number:
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On-line Access:
2025-02-26
Received:
2024-03-11
Revision Accepted:
2024-06-29
Crosschecked:
2025-02-27