Abstract: The wrist joint is a highly mobile functional joint. Wrist conditions including traumatic and degenerative arthritis, rheumatoid arthritis, and giant cell tumors of the distal radius, cause significant pain and mobility impairment. In joint surgery, the decision to use joint prostheses to reconstruct joint function is greatly influenced by the characteristics of the prosthesis (Mok et al., 2016). However, traditional implants have limitations such as shape mismatch, inadequate implant�bone interface strength which causes loosening, and poor bone ingrowth (Zhang et al., 2014).

Key words: Polycomb repressive complexes (PRC); CBX proteins; Epigenetic regulation; Cancer

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