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Journal of Zhejiang University SCIENCE B
ISSN 1673-1581(Print), 1862-1783(Online), Monthly
2025 Vol.26 No.11 P.1037-1058
Food-derived bioactive peptides: health benefits, structure‒activity relationships, and translational prospects
Abstract: Food-derived bioactive peptides (FBPs), particularly those with ten or fewer amino acid residues and a molecular weight below 1300 Da, have gained increasing attention for their safe, diverse structures and specific biological activities. The development of FBP-based functional foods and potential medications depends on understanding their structure‒activity relationships (SARs), stability, and bioavailability properties. In this review, we provide an in-depth overview of the roles of FBPs in treating various diseases, including Alzheimer’s disease, hypertension, type 2 diabetes mellitus, liver diseases, and inflammatory bowel diseases, based on the literature from July 2017 to Mar. 2023. Subsequently, attention is directed toward elucidating the associations between the bioactivities and structural characteristics (e.g., molecular weight and the presence of specific amino acids within sequences and compositions) of FBPs. We also discuss in silico approaches for FBP screening and their limitations. Finally, we summarize recent advancements in formulation techniques to improve the bioavailability of FBPs in the food industry, thereby contributing to healthcare applications.
Key words: Functional foods; Biological compound; In silico prediction; Bioavailability; Oral delivery; Absorption
1浙江大学医学院药理学系，中国杭州市，310058
2浙江大学医学院附属第二医院，教育部消化系统肿瘤医学研究与创新研究中心，中国杭州市，310009
3浙江大学长三角创新中心，中国嘉兴市，314100
4中国食品药品检定研究院，中国北京市，102629
5浙江大学化学与生物工程学院，生物质化工教育部重点实验室，中国杭州市，310058
6浙江大学舟山海洋研究中心，中国舟山市，316021
7浙江大学生命科学学院，中国杭州市，310058
8浙江大学医学院细胞生物学系，中国杭州市，310058
9中国华润三九医药股份有限公司，中国深圳市，518110
10浙江大学肿瘤研究中心，中国杭州市，310058
11阿尔伯塔大学埃德蒙顿分校农业、食品和营养科学系，加拿大阿尔伯塔，100027
12浙江大学动物科学学院，中国杭州市，310058
摘要：食源性生物活性肽（FBP），特别是那些氨基酸残基少于10个且分子量低于1300 Da的肽，因其安全、多样化的结构和特定的生物活性而受到越来越多的关注。基于FBP的功能性食品和潜在药物的开发取决于对其构效关系（SAR）、稳定性和生物利用度特性的理解。在这篇综述中，我们基于过去五年的文献，深入概述了FBP在治疗各种疾病中的作用，包括阿尔茨海默病、高血压、2型糖尿病、肝病和炎症性肠病。随后，我们聚焦于阐明FBP的生物活性与结构特征（例如分子量、氨基酸序列和组成中特定氨基酸的存在）之间的关联，还讨论了筛选FBP的计算机模拟方法及其局限性。最后，我们总结了剂型技术的最新进展，以提高食品工业中FBP的生物利用度，从而为医疗保健应用做出贡献。
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DOI:
10.1631/jzus.B2400106
CLC number:
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On-line Access:
2025-11-19
Received:
2024-02-29
Revision Accepted:
2024-07-29
Crosschecked:
2025-11-19