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Journal of Zhejiang University SCIENCE B
ISSN 1673-1581(Print), 1862-1783(Online), Monthly
2025 Vol.26 No.8 P.763-777
Effects of Citrus on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health
Abstract: Citrus, which has been consumed internationally for a long time, is widely used as a health food. Citrus and its active components exert significant effects on oxidative stress and lipid metabolism, which are closely associated with female reproductive health. Studies suggest that citrus-derived compounds may alleviate oxidative stress by activating signaling pathways such as nuclear factor erythroid 2-related factor 2 (Nrf2) and Sirtuin 1 (SIRT1), and improve lipid metabolism through the activation of pathways such as peroxisome proliferator-activated receptor α (PPARα). This review focuses on the effects of Citrus on oxidative stress and lipid metabolism, aiming to provide new insights for promoting female reproductive health; however, further work is needed to elucidate the mechanisms involved and validate the therapeutic potential of Citrus’s bioactive components in clinical settings.
Key words: Citrus; Food; Female reproductive health; Oxidative stress; Lipid metabolism
浙江工商大学食品与生物工程学院,中国杭州市,310018
摘要:柑橘在国际上拥有悠久的食用历史,广泛被用作健康食品。柑橘及其活性成分对氧化应激和脂质代谢具有显著的调节作用,这些因素与女性生殖健康密切相关。研究表明,柑橘来源的化合物可能通过激活Nrf2和SIRT1等信号通路缓解氧化应激,并通过激活包括PPARα在内的信号通路改善脂质代谢。本文综述了柑橘对氧化应激和脂质代谢的影响,旨在为促进女性生殖健康提供新思路。然而,仍需进一步的研究明确其作用机制,且柑橘活性成分的临床治疗潜力仍有待验证。
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DOI:
10.1631/jzus.B2500127
CLC number:
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On-line Access:
2025-08-25
Received:
2025-03-17
Revision Accepted:
2025-05-27
Crosschecked:
2025-08-25