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Journal of Zhejiang University SCIENCE B

ISSN 1673-1581(Print), 1862-1783(Online), Monthly

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Review

Review: Mesenchymal stem cells as therapeutic agents and in gene delivery for the treatment of glioma

Bing-yu Xiang, Lu Chen, Xiao-jun Wang, Charlie Xiang

DOI: 10.1631/jzus.B1600337 Downloaded: 2785 Clicked: 4756 Cited: 0 Commented: 0(p.737-746) <Full Text><PPT> 1834

Chinese summary   <28>  间充质干细胞在胶质瘤治疗中的作用研究

概要:胶质瘤是颅内发病率最高的恶性肿瘤,虽然临床上可以用"手术+化疗"的方法进行治疗,但由于其浸润性,对化疗药物的低敏感性等原因,常在治疗后复发,严重威胁人类生命健康。间充质干细胞(MSC)是干细胞中的一员,具有增殖能力强、分化潜能大、免疫原性低及采集方便等优点,其趋化性更使MSC成为肿瘤治疗的一个理想工具。本文对干细胞治疗胶质瘤的研究现状进行了归纳总结,着重阐述了MSC的旁分泌途径作用及作为基因载体导入肿瘤坏死因子相关凋亡诱导配体(TRAIL)、溶瘤病毒等其他治疗基因的生物功能,以期对进一步的治疗研究提供帮助。

关键词组:癌症;间充质干细胞;胶质瘤;细胞治疗

Articles

Global changes of 5-hydroxymethylcytosine and 5-methylcytosine from normal to tumor tissues are associated with carcinogenesis and prognosis in colorectal cancer

Yi-ping Tian, Ai-fen Lin, Mei-fu Gan, Hao Wang, Dan Yu, Chong Lai, Dan-dan Zhang, Yi-min Zhu, Mao-de Lai

DOI: 10.1631/jzus.B1600314 Downloaded: 2800 Clicked: 4943 Cited: 0 Commented: 0(p.747-756) <Full Text><PPT> 1943

Chinese summary   <>  正常组织与肿瘤组织中总体5hmC和5mC水平的变化程度与结直肠癌肿瘤发生及预后有关

目的:研究DNA总体甲基化、羟甲基化水平与结直肠癌发生、发展及预后的关系。
创新点:采用肿瘤与正常组织总体5-甲基胞嘧啶(5mC)、5-羟甲基胞嘧啶(5hmC)的比值并探讨其与结直肠癌临床病理变化和预后的关系。
方法:采用酶联免疫吸附试验(ELISA)方法检测肿瘤与相应正常组织基因组中总体5hmC和5mC水平。
结论:C/N-5mC比值的水平对结直肠癌的预后是一个独立的保护性因子(P=0.04)。当病人同时具有高水平的C/N-5hmC和低水平的C/N-5mC,其预后更差(P<0.01)。因此,可以使用5mC和5hmC对结直肠癌的发生和预后进行评估。

关键词组:5-羟甲基胞嘧啶;5-甲基胞嘧啶;预后;结直肠癌

Toxicity comparison of different active fractions extracted from radix Sophorae tonkinensis in zebrafish

Hong-cui Liu, Xiao-yu Zhu, Jiang-hua Chen, Sheng-ya Guo, Chun-qi Li, Zhong-ping Deng

DOI: 10.1631/jzus.B1600158 Downloaded: 2836 Clicked: 5126 Cited: 0 Commented: 0(p.757-769) <Full Text><PPT> 1757

Protective effect of dihydropteridine reductase against oxidative stress is abolished with A278C mutation

Yan-ting Gu, Yan-chun Wang, Hao-jun Zhang, Ting-ting Zhao, Si-fan Sun, Hua Wang, Bin Zhu, Ping Li

DOI: 10.1631/jzus.B1600123 Downloaded: 2729 Clicked: 4938 Cited: 0 Commented: 0(p.770-777) <Full Text><PPT> 1859

Adhesion of bone marrow mesenchymal stem cells on porous titanium surfaces with strontium-doped hydroxyapatite coating

Dan-li Fu, Qiao-hong Jiang, Fu-ming He, Bai-ping Fu

DOI: 10.1631/jzus.B1600517 Downloaded: 2929 Clicked: 5502 Cited: 0 Commented: 0(p.778-788) <Full Text><PPT> 1958

Neuroprotection of dexmedetomidine against propofol-induced neuroapoptosis partly mediated by PI3K/Akt pathway in hippocampal neurons of fetal rat

Ning Zhang, Quan-ping Su, Wei-xia Zhang, Nian-jun Shi, Hao Zhang, Ling-ping Wang, Zhong-kai Liu, Ke-zhong Li

DOI: 10.1631/jzus.B1600476 Downloaded: 2660 Clicked: 4770 Cited: 0 Commented: 0(p.789-796) <Full Text><PPT> 1934

Antioxidant activity of alcohol aqueous extracts of Crypthecodinium cohnii and Schizochytrium sp.

Jin-hui Yu, Yu Wang, Jie Sun, Fei Bian, Gao Chen, Yan Zhang, Yu-ping Bi, Ying-jie Wu

DOI: 10.1631/jzus.B1600367 Downloaded: 4060 Clicked: 6302 Cited: 0 Commented: 1(p.797-806) <Full Text><PPT> 2019

Application of a chitosan coating as a carrier for natamycin to maintain the storage quality of ground cherry (Physalis pubescens L.)

Xiao-lei Hao, Jiao-jiao Zhang, Xi-hong Li, Wei Wang

DOI: 10.1631/jzus.B1600295 Downloaded: 2686 Clicked: 4357 Cited: 0 Commented: 0(p.807-815) <Full Text><PPT> 1782

Antimelanogenic effects of Inula britannica flower petal extract fermented by Lactobacillus plantarum KCCM 11613P

Eun-hye Park, Won-young Bae, Jae-yeon Kim, Kee-tae Kim, Hyun-dong Paik

DOI: 10.1631/jzus.B1600234 Downloaded: 2570 Clicked: 5005 Cited: 0 Commented: 0(p.816-824) <Full Text><PPT> 1653

Report

An analysis of patents for anesthetic laryngoscopes

Cheng-dong Ji, Xin Pan, Yuan-chang Xiong, Xuan Guo, Shu-wen Qian, Chang Xu, Qiang-qiang Fu, Zhi-ping Yang, Yu Ma, Yue-zhu Wan

DOI: 10.1631/jzus.B1600259 Downloaded: 2857 Clicked: 5082 Cited: 0 Commented: 0(p.825-832) <Full Text><PPT> 1657

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