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Abstract: Background and objective: non-alcoholic fatty liver disease (NAFLD) is associated with arterial stiffness in the general population. Age, obesity, hypertension, and diabetics are risk factors for arterial stiffness. In this study, we aimed to investigate the association between NAFLD and arterial stiffness as measured by brachial-ankle pulse wave velocity (baPWV) in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population. Methods: A cross-sectional study with 1296 non-obese, non-hypertensive, and non-diabetic young and middle-aged (20–65 years) subjects undergoing routine medical check-ups in the International Health Care Center of the Second Affiliated Hospital of School of Medicine of Zhejiang University was carried out. Fatty liver was diagnosed by ultrasonography, and baPWV was measured using an automatic waveform analyzer. The subjects were classified into two groups according to the presence of NAFLD, and divided into a further two groups according to their baPWV. Results: The overall incidence of NAFLD was 19.0%, and NAFLD patients had a significantly higher level of baPWV than the controls ((1321±158) cm/s vs. (1244±154) cm/s; P<0.001). The incidence of NAFLD was clearly higher in the increased baPWV group than in the normal baPWV group (29.3% vs. 16.9%; P<0.001), and the incidence increased in line with the increase of baPWV quartiles in the normal range as well as with the severity of arterial stiffness (both P for trend <0.001). Multiple linear logistic regression analysis showed that the presence of NAFLD was positively and independently associated with baPWV. Conclusions: Our results suggest that the presence of NAFLD is associated with arterial stiffness as measured by baPWV in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population.

非肥胖、高血压和糖尿病的中国中青年人群中非酒精性脂肪性肝病和动脉硬度的关系研究

研究目的：探讨在非肥胖、高血压和糖尿病的中国中青年群人中非酒精性脂肪性肝病（NAFLD）和动脉硬度的关系。
创新要点：在非肥胖、高血压和糖尿病的中青年人群中，阐明NAFLD和动脉硬度的关系，对预防和诊断早期动脉硬度有重要临床意义。
研究方法：在非肥胖、高血压和糖尿病的中青年体检人群中进行一项大型横断面研究。用B超诊断脂肪肝，用臂踝脉搏波指数（baPWV）测量动脉硬度，根据是否有NAFLD和baPWV水平分组。
重要结论：NAFLD组患者的baPWV水平明显高于对照组（(1321±158)cm/svs.(1244±154)cm/s；P<0.001），NAFLD患病率在baPWV升高组明显高于baPWV正常组（29.3%vs.16.9%；P<0.001），且NAFLD患病率随baPWV水平和动脉硬度程度的升高而升高（两者趋势P值<0.001）。多因素线性回归分析表明，NAFLD发生与baPWV独立相关。因此，在非肥胖、高血压和糖尿病的中国中青年群人中，NAFLD发生与动脉硬度密切相关。
非酒精性脂肪性肝病；动脉硬度；臂踝脉搏波指数；危险因素

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