Articles in Press: <JZUS-B>


Journal of Zhejiang University SCIENCE B

ISSN 1673-1581(Print), 1862-1783(Online), Monthly

CONTENTS

Autophagy in skeletal muscle dysfunction of chronic obstructive pulmonary disease: implications, mechanisms, and perspectives

Xiaoyu HAN, Peijun LI, Meiling JIANG, Yuanyuan CAO, Yingqi WANG, Linhong JIANG, Xiaodan LIU, Weibing WU

DOI: 10.1631/jzus.B2300680 Downloaded: 591 Clicked: 1042 Cited: 0 Commented: 0(p.) <Full Text>

Treatment of large bone defects in load-bearing bone: traditional and novel bone grafts

Dan YU, Wenyi SHEN, Jiahui DAI, Huiyong ZHU

DOI: 10.1631/jzus.B2300669 Downloaded: 751 Clicked: 813 Cited: 0 Commented: 0(p.) <Full Text>

OX40L promotes follicular helper T cell differentiation and function in mice with immune thrombocytopenia

Ziyin YANG, Lei HAI, Xiaoyu CHEN, Siwen WU, Yan LV, Dawei CUI, Jue XIE

DOI: 10.1631/jzus.B2300947 Downloaded: 598 Clicked: 781 Cited: 0 Commented: 0(p.) <Full Text>

The structure of myelin in the central nervous system and another possible driving force for its formation—myelin compaction

Qi SHAO, Simin CHEN, Tian XU, Yuyu SHI, Zijin SUN, Qingguo WANG, Xueqian WANG, Fafeng CHENG

DOI: 10.1631/jzus.B2300776 Downloaded: 672 Clicked: 844 Cited: 0 Commented: 0(p.) <Full Text>

The protective effect of folic acid on oxidative stress induced by lead acetate in PC12 cells

Ning LI1, Mingming LI, Xianqing HUANG, Lianjun SONG, Mingwu QIAO, Tianlin WANG, Tiange LI, Xiuhong ZHU, Can CUI

DOI: 10.1631/jzus.B2100938 Downloaded: 1316 Clicked: 2127 Cited: 0 Commented: 141(p.) <Full Text>

High-dose estrogen impairs demethylation of H3K27me3 by decreasing Kdm6b expression in ovarian hyperstimulation in mice

Quanmin KANG, Fang LE, Xiayuan XU, Lifang CHEN, Shi ZHENG, Lijun LOU, Nan JIANG, Ruimin ZHAO, Yuanyuan ZHOU, Juan SHEN, Minhao HU, Ning WANG, Qiongxiao HUANG, Fan JIN

DOI: 10.1631/jzus.B2300681 Downloaded: 507 Clicked: 724 Cited: 0 Commented: 0(p.) <Full Text>

SLC2A3 promotes colorectal cancer metastasis by triggering the YAP-1/PDGFB axis

Jinlong TANG, Minglang MAI, Fengyan HAN, Chaoyi CHEN, Shuli XIA, Xueping XIANG, Qi YANG, Kefeng DING

DOI: 10.1631/jzus.B2300652 Downloaded: 532 Clicked: 927 Cited: 0 Commented: 0(p.) <Full Text>

Cellulose nanofibril matrix drives the dynamic formation of spheroids

Yi LU, Guo LI, Yeqiu LI, Yuan YAO

DOI: 10.1631/jzus.B23Z0003 Downloaded: 705 Clicked: 1081 Cited: 0 Commented: 0(p.) <Full Text>

Comparative study of bladder augmentation using PLLA-based biomimetic scaffolds: electrospun nanofiber vs. extracellular matrix scaffold with adipose-derived stem cells

Xuesheng WANG, Dezhi ZHOU, Liliang OUYANG, Fan ZHANG, Xu TAO,Limin LIAO

DOI: 10.1631/jzus.B2300275 Downloaded: 710 Clicked: 1180 Cited: 0 Commented: 0(p.) <Full Text>

SP7 transcription factor ameliorates bone defect healing in low-density lipoprotein receptor-related protein 5-dependent osteoporosis mice

Yue XI, Qifeng JIANG, Wei DAI, Chaozhen CHEN, Yang WANG, Xiaoyan MIAO, Kaichen LAI, Zhiwei JIANG, Guoli YANG, Ying WANG

DOI: 10.1631/jzus.B2300531 Downloaded: 720 Clicked: 903 Cited: 0 Commented: 0(p.) <Full Text>

Effects of glyphosate, antibiotics and an anticoccidial drug on pancreatic gene expression and blood physiology in broilers

Georgi Yu. LAPTEV, Daria G. TIURINA, Elena A. YILDIRIM, Elena P. GORFUNKEL, Larisa A. ILINA, Valentina A. FILIPPOVA, Andrei V. DUBROVIN, Alisa S. DUBROVINA, Evgeni A. BRAZHNIK, Natalia I. NOVIKOVA, Veronika Kh. MELIKIDI, Kseniya A. KALITKINA, Ekaterina S. PONOMAREVA, Vasiliy A. ZAIKIN, Darren K. GRIFFIN, Michael N. ROMANOV

DOI: 10.1631/jzus.B2300767 Downloaded: 536 Clicked: 676 Cited: 0 Commented: 0(p.) <Full Text>

Repetitive transcranial magnetic stimulation combined with imaginal exposure therapy for adolescents with acute stress disorder: case report

Miaomiao ZhAO, Ying LI, Haoyang ZHAO, Chaonan JIANG,Manli HUANG

DOI: 10.1631/jzus.B2300765 Downloaded: 444 Clicked: 629 Cited: 0 Commented: 0(p.) <Full Text>

Co-culture of natural killer cells and tumor spheroids on a heterogeneous multilayer paper stack

Yuanyuan XIE, Xiaoyan YANG, Rong PAN, Lixia GAO, Ling YU

DOI: 10.1631/jzus.B2300617 Downloaded: 503 Clicked: 742 Cited: 0 Commented: 0(p.) <Full Text>

Mitochondria derived from hESC-MSCs alleviate inflammatory response in HGFs

Bicong GAO, Chenlu SHEN, Kejia LV, Xuehui LI, Yongting ZHANG, Fan SHI, Hongyan DIAO, Hua YAO

DOI: 10.1631/jzus.B2300928 Downloaded: 352 Clicked: 647 Cited: 0 Commented: 0(p.) <Full Text>

Single-cell transcriptome analysis reveals abnormal angiogenesis and placentation by loss of imprinted glutaminyl-peptide cyclotransferase

Jing GUO, Jihong ZHENG, Ruixia LI, Jindong YAO, He ZHANG, Xu WANG, Chao ZHANG

DOI: 10.1631/jzus.B2400099 Downloaded: 232 Clicked: 387 Cited: 0 Commented: 0(p.) <Full Text>

Thirteen serum biochemical indexes and five whole blood coagulation indices in a point-of-care testing analyzer: ideal protocol for evaluating pulmonary and critical care medicine

Mingtao LIU, Li LIU, Jiaxi CHEN, Zhifeng HUANG, Huiqing ZHU, Shengxuan LIN, Weitian QI, Zhangkai J. CHENG, Ning LI, Baoqing SUN

DOI: 10.1631/jzus.B2300433 Downloaded: 708 Clicked: 1120 Cited: 0 Commented: 0(p.) <Full Text>

Immune checkpoint blockade for cancer therapy: current progress and perspectives

Hongying YE, Weijie LIAO, Jiongli PAN, Yin SHI, Qingqing WANG

DOI: 10.1631/jzus.B2300492 Downloaded: 899 Clicked: 926 Cited: 0 Commented: 0(p.) <Full Text>

Advancements in molecular imaging probes for precision diagnosis and treatment of prostate cancer

Jiajie FANG, Ahmad ALHASKAWI, Yanzhao DONG, Cheng CHENG, Zhijie XU, Junjie TIAN, Sahar Ahmed ABDALBARY, Hui LU

DOI: 10.1631/jzus.B2300614 Downloaded: 756 Clicked: 902 Cited: 0 Commented: 0(p.) <Full Text>

Energy deprivation-induced Autophagy and Aggrephagy: insights from yeast and mammals

Siyu FAN, Yingcong CHEN, Weijing YAO, Cong YI

DOI: 10.1631/jzus.B2300884 Downloaded: 535 Clicked: 780 Cited: 0 Commented: 0(p.) <Full Text>

COVID-19 and acute limb ischemia: latest hypotheses of pathophysiology and molecular mechanisms

Chengjun YAO, Yanzhao DONG, Haiying ZHOU, Xiaodi ZOU, AHMAD ALHASKAWI, Sohaib Hasan Abdullah EZZI, Zewei WANG, Jingtian LAI, Vishnu Goutham KOTA, Mohamed Hasan Abdulla Hasan ABDULLA, Zhenfeng LIU, Sahar Ahmed ABDALBARY, Olga ALENIKOVA, Hui LU

DOI: 10.1631/jzus.B2300512 Downloaded: 586 Clicked: 926 Cited: 0 Commented: 0(p.) <Full Text>

The role of lncRNA in the crosstalk between osteogenesis and angiogenesis in the bone microenvironment

Shihua ZHANG, Jianmin GUO, Yuting HE, Zhiang SU, Yao FENG, Lan ZHANG, Jun ZOU, Xiquang WENG, Yu YUAN

DOI: 10.1631/jzus.B2300607 Downloaded: 676 Clicked: 858 Cited: 0 Commented: 0(p.) <Full Text>

Advancements in mechanisms and drug treatments for fibrodysplasia ossificans progressiva

Yijun ZHOU, Ce SHI, Hongchen SUN

DOI: 10.1631/jzus.B2300779 Downloaded: 514 Clicked: 677 Cited: 0 Commented: 0(p.) <Full Text>

Single-cell and spatial transcriptomic analysis reveals that an immune cell-related signature could predict clinical outcomes for microsatellite stable colorectal cancer patients receiving immunotherapy

Shijin YUAN, Yan XIA, Guangwei DAI, Shun RAO, Rongrong HU, Yuzhen GAO, Qing QIU, Chenghao WU, Sai QIAO, Yinghua XU, Xinyou XIE, Haizhou LOU, Xian WANG, Jun ZHANG

DOI: 10.1631/jzus.B2300679 Downloaded: 654 Clicked: 847 Cited: 0 Commented: 0(p.) <Full Text>

Implications of bacteria-bacteria interactions within plant microbiota for plant health and productivity

Giovanni Davide BARONE, Yaqi ZHOU, Hongkai WANG, Sunde XU, Zhonghua MA, Tomislav CERNAVA, Yun CHEN

DOI: 10.1631/jzus.B2300914 Downloaded: 487 Clicked: 776 Cited: 0 Commented: 0(p.) <Full Text>

Olig2+ single-colony-derived cranial bone-marrow mesenchymal stem cells achieve improved regeneration in a cuprizone-induced demyelination mouse model

Deqing PENG, Ruijie LU, Leyao LV, Qing YAO, Kaichuang YANG, Yunfeng XU, Xiaoming FENG, Ruolang PAN, Yuyuan MA

DOI: 10.1631/jzus.B2300790 Downloaded: 532 Clicked: 1047 Cited: 0 Commented: 0(p.) <Full Text>

Role of PANoptosis and related genes in acute liver failure: neoteric insight from bioinformatic analysis and animal experiment verification

Tiantian GE, Yao CHEN, Lantian PANG, Junwei SHAO, Zhi CHEN

DOI: 10.1631/jzus.B2300678 Downloaded: 349 Clicked: 609 Cited: 0 Commented: 0(p.) <Full Text>

Chronic exposure to hexavalent chromium induces esophageal tumorigenesis via activating the Notch signaling pathway

Yilin ZHU, Fanrong LIU, Lei LIU, Jinfu WANG, Fengyuan GAO, Lan YE, Honglei WU, Chengjun ZHOU, Guimei LIN, Xiaogang ZHAO, Peichao LI

DOI: 10.1631/jzus.B2300896 Downloaded: 406 Clicked: 841 Cited: 0 Commented: 0(p.) <Full Text>

Epigenetic factors associated with peri-implantitis: a review

Qianhui LI, Hongye LU, Mengyuan ZHANG, Yuting YE, Qianming CHEN, Ping SUN

DOI: 10.1631/jzus.B2400032 Downloaded: 356 Clicked: 553 Cited: 0 Commented: 0(p.) <Full Text>

Preclinical models in the study of lymph node metastasis

Liya WEI, Zizhan LI, Niannian ZHONG, Leiming CAO, Guangrui WANG, Yao XIAO, Bo CAI, Bing LIU, Linlin BU

DOI: 10.1631/jzus.B2400052 Downloaded: 369 Clicked: 434 Cited: 0 Commented: 0(p.) <Full Text>

Two-step internal/external polydopamine (Cu2+) modified bioceramic scaffolds enhance antibacterial and alveolar bone regeneration capability

Xiaojian JIANG, Lihong LEI, Weilian SUN, Yingming WEI, Jiayin HAN, Shuaiqi ZHONG, Xianyan YANG, Zhongru GOU, Lili CHEN

DOI: 10.1631/jzus.B23Z0004 Downloaded: 1012 Clicked: 1204 Cited: 0 Commented: 0(p.) <Full Text>

New perspectives on microbiome-dependent gut-brain pathways for the treatment of depression with gastrointestinal symptoms: from bench to bedside

Menglin LIU, Genhao FAN, Lingkai MENG, Kuo YANG, Huayi LIU

DOI: 10.1631/jzus.B2300343 Downloaded: 1380 Clicked: 849 Cited: 0 Commented: 0(p.) <Full Text>

ATP-binding cassette (ABC) transporters: structures and roles in bacterial pathogenesis

Shu Sian HOW, Sylvia CHIENG, Sheila NATHAN, Su Datt LAM

DOI: 10.1631/jzus.B2300641 Downloaded: 2052 Clicked: 797 Cited: 0 Commented: 0(p.) <Full Text>

Input-output specific orchestration of aversive valence in lateral habenula during stress dynamics

Taida HUANG, Xiaonan GUO, Xiaomin HUANG, Chenju YI, Yihui CUI, Yiyan DONG

DOI: 10.1631/jzus.B2300933 Downloaded: 809 Clicked: 1054 Cited: 0 Commented: 0(p.) <Full Text>

Promising protective treatment potential of endophytic bacterium Rhizobium aegyptiacum for ulcerative colitis in rats

Engy ELEKHNAWY, Duaa ELIWA, Sebaey MAHGOUB, Sameh MAGDELDIN, Ehssan MOGLAD, Sarah IBRAHIM, Asmaa Ramadan AZZAM, Rehab AHMED, Walaa A. NEGM

DOI: 10.1631/jzus.B2300777 Downloaded: 645 Clicked: 980 Cited: 0 Commented: 0(p.) <Full Text>

Applications of bioactive peptides in cosmeceuticals: a review

Tolulope Joshua ASHAOLU

DOI: 10.1631/jzus.B2400029 Downloaded: 621 Clicked: 703 Cited: 0 Commented: 0(p.) <Full Text>

Association between post-COVID-19 sleep disturbance and neurocognitive function: A comparative study based on propensity score matching

Shixu DU, Leqin FANG, Yuanhui LI, Shuai LIU, Xue LUO, Shufei ZENG, Shuqiong ZHENG, Hangyi YANG, Yan XU, Dai LI, Bin ZHANG

DOI: 10.1631/jzus.B2300831 Downloaded: 425 Clicked: 721 Cited: 0 Commented: 0(p.) <Full Text>

Pharmacological inhibition of ENaC or NCX can attenuate hepatic ischemia-reperfusion injury exacerbated by hypernatremia

Yabin CHEN, Hao LI, Peihao WEN, Jiakai ZHANG, Zhihui WANG, Shengli CAO, Wenzhi GUO

DOI: 10.1631/jzus.B2300825 Downloaded: 397 Clicked: 743 Cited: 0 Commented: 0(p.) <Full Text>

Mechanisms of ribosomopathy and phase separation-related ribosomopathy

Zhiyuan PAN, Guofen LIN, Hao LIU, Guozhi LI, Xiaoyi ZHANG, Jiewen DAI

DOI: 10.1631/jzus.B2300904 Downloaded: 432 Clicked: 669 Cited: 0 Commented: 0(p.) <Full Text>

A practice guideline for therapeutic drug monitoring of mycophenolic acid for solid organ transplants

Shuang LIU, Hongsheng CHEN, Zaiwei SONG, Qi GUO, Xianglin ZHANG, Bingyi SHI, Suodi ZHAI, Lingli ZHANG, Liyan MIAO, Liyan CUI, Xiao CHEN, Yalin DONG, Weihong GE, Xiaofei HOU, Ling JIANG, Long LIU, Lihong LIU, Maobai LIU, Tao LIN, Xiaoyang LU, Lulin MA, Changxi WANG, Jianyong WU, Wei WANG, Zhuo WANG, Ting XU, Wujun XUE, Bikui ZHANG, Guanren ZHAO, Jun ZHANG, Limei ZHAO, Qingchun ZHAO, Xiaojian ZHANG, Yi ZHANG, Yu ZHANG, Rongsheng ZHAO

DOI: 10.1631/jzus.B2400069 Downloaded: 312 Clicked: 437 Cited: 0 Commented: 0(p.) <Full Text>

Endomitosis: a new cell fate in the cell cycle leading to polyploidy in megakaryocytes and hepatocytes

Qi-Hua HUA, Xuechun ZHANG, Ruifeng TIAN, Zhigang SHE, Zan HUANG

DOI: 10.1631/jzus.B2400127 Downloaded: 207 Clicked: 273 Cited: 0 Commented: 0(p.) <Full Text>

Epidemiology and pathogenesis of the link between rheumatoid arthritis and periodontitis

Huiya FANG, Jin LIN, Yiwu QIU, Zijian CHENG, Weiqian CHEN

DOI: 10.1631/jzus.B2300519 Downloaded: 730 Clicked: 880 Cited: 0 Commented: 0(p.) <Full Text>

Fibroblast growth factors and endometrial decidualization: models, mechanisms and related pathologies

Xueni ZHANG, Yidi MO, Chunbin LU, Zhijian SU, Xiaokun LI

DOI: 10.1631/jzus.B2300830 Downloaded: 477 Clicked: 668 Cited: 0 Commented: 0(p.) <Full Text>

Alamandine inhibits pathological retinal neovascularization by targeting MrgD-mediated HIF-1α/VEGFA pathway

Kun ZHAO, Yaping JIANG, Wen HUANG, Yukang MAO, Yihui CHEN, Peng LI, Chuanxi YANG

DOI: 10.1631/jzus.B2300862 Downloaded: 465 Clicked: 813 Cited: 0 Commented: 0(p.) <Full Text>

Identification of key genes associated with epithelial barrier dysfunction for patients with asthma using comprehensive analysis and experimental validation

Shixiu LIANG, Xiaodi ZHU, Siqi WANG, Xi CHEN, Yanwen LI, Shiting YI, Yingjun CHEN

DOI: 10.1631/jzus.B2300943 Downloaded: 447 Clicked: 1098 Cited: 0 Commented: 0(p.) <Full Text>

Competitive roles of SO/delta-nesting-mediated sleep disruption under acute methamphetamine exposure in monkeys

Xin LV, Jie LIU, Shuo MA, Yuhan WANG, Yixin PAN, Xian QIU, Bomin SUN, Shikun ZHAN

DOI: 10.1631/jzus.B2400048 Downloaded: 338 Clicked: 478 Cited: 0 Commented: 0(p.) <Full Text>

Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases

Qihui ZHOU, Panpan CEN, Zhi CHEN, Jie JIN

DOI: 10.1631/jzus.B2400053 Downloaded: 357 Clicked: 530 Cited: 0 Commented: 0(p.) <Full Text>

CXCL16 promotes proliferation of head and neck squamous cell carcinoma by regulating GPX1-mediated antioxidant levels

Ru HE, Hongyi JIANG, Chengchi ZHANG, Yuan CHEN, Wenshun LIU, Xinyue DENG, Xiaozheng ZHU, Yunye LIU, Chuanming ZHENG, Yining ZHANG, Chengying SHAO, Yanting DUAN, Jiajie XU

DOI: 10.1631/jzus.B2400192 Downloaded: 328 Clicked: 576 Cited: 0 Commented: 0(p.) <Full Text>

Functional redundancy of three mitochondrial Mg2+/Mn2+-dependent protein phosphatases (PPMs) in Toxoplasma gondii

Kaiyin SHENG, Xueqiu CHEN, Yimin YANG, Jie XIA, Kaiyue SONG, Chaoqun YAO, Yi YANG, Aifang DU, Guangxu MA

DOI: 10.1631/jzus.B2400308 Downloaded: 177 Clicked: 339 Cited: 0 Commented: 0(p.) <Full Text>

Aberrant network topological structure of sensorimotor superficial white-matter system in major depressive disorder

Peng WANG, Yanling BAI, Yang XIAO, Yuhong ZHENG, Li SUN, the DIRECT Consortium, Jinhui WANG, Shao-Wei XUE

DOI: 10.1631/jzus.B2300880 Downloaded: 461 Clicked: 809 Cited: 0 Commented: 0(p.) <Full Text>

Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect related diseases

Xiaodan HUANG, Yue FANG, Jie SONG, Yuanjing HAO, Yuanyuan CAI, Pengfei WEI, Na ZHANG

DOI: 10.1631/jzus.B2400186 Downloaded: 411 Clicked: 599 Cited: 0 Commented: 0(p.) <Full Text>

Application of custom-made joint prostheses in wrist

Xiaodi ZOU, Yanzhao DONG, Changxin WANG, Hui LU

DOI: 10.1631/jzus.B2400102 Downloaded: 304 Clicked: 533 Cited: 0 Commented: 0(p.) <Full Text>

Pediatric inflammatory bowel disease in mother-child pairs: clinical risk factors and gut microbiota characteristics

Cunzheng ZHANG, Ruqiao DUAN, Nini DAI, Yuzhu CHEN, Gaonan LI, Xiaoang LI, Xiaolin JI, Xuemei ZHONG, Zailing LI, Liping DUAN

DOI: 10.1631/jzus.B2400330 Downloaded: 237 Clicked: 382 Cited: 0 Commented: 0(p.) <Full Text>

Abnormal functional connectivity of theory of mind and mirror neuron system is associated with social deficits in autism spectrum disorder

Qiurong ZHANG, Chen YANG, Xingke WANG, Wenqiang DONG, Shengzhi MA, Lixia YUAN

DOI: 10.1631/jzus.B2300719 Downloaded: 455 Clicked: 778 Cited: 0 Commented: 0(p.) <Full Text>

Dynamic changes in physiochemical, structural and flavor characteristics of ginger-juice milk curd

Haifeng PAN, Wenna BAO, Yi CHEN, Hongxiu LIAO

DOI: 10.1631/jzus.B2400269 Downloaded: 402 Clicked: 588 Cited: 0 Commented: 0(p.) <Full Text>

3D printing-assisted freeze-casting of processed pyritum-doped β-TCP biomimetic scaffold with angiogenesis and bone regeneration capability

Chenxu WEI, Zongan LI,, Xiaoyun LIANG,, Yuwei ZHAO, Xingyu ZHU, Haibing HUA, Guobao CHEN, Kunming QIN, Zhipeng CHEN, Changcan SHI, Feng ZHANG, Weidong LI

DOI: 10.1631/jzus.B2400340 Downloaded: 244 Clicked: 440 Cited: 0 Commented: 0(p.) <Full Text>

Efficacy of adjunctive systemic or local antibiotics therapy in peri-implantitis: a systematic review and meta-analysis of randomized controlled clinical trials

Yifan LU, Siqi BAO, Hongke LUO, Qianming CHEN, Misi SI

DOI: 10.1631/jzus.B2300730 Downloaded: 470 Clicked: 658 Cited: 0 Commented: 0(p.) <Full Text>

Unmet needs of patients with intravascular large B-cell lymphoma: Three case reports and a literature review

Xian LI, Ru LUO, Jiaming XU, Xueli JING, Weiqin WANG, Xibin XIAO, Wenbin QIAN

DOI: 10.1631/jzus.B2300941 Downloaded: 365 Clicked: 510 Cited: 0 Commented: 0(p.) <Full Text>

Metapangenomics reveals an increased proportion of an Escherichia coli-dominated enterotype in older Chinese people

Jinyou LI, Yue WU, Yichen YANG, Lufang CHEN, Caihong HE, Shixian ZHOU, Shunmei HUANG, Xia ZHANG, Yuming WANG, Qifeng GUI, Haifeng LU, Qin ZHANG, and Yunmei YANG

DOI: 10.1631/jzus.B2400341 Downloaded: 199 Clicked: 264 Cited: 0 Commented: 0(p.) <Full Text>

Deciphering odontogenic myxoma: The role of copy number variations as diagnostic signatures

Aobo ZHANG, Jianyun ZHANG, Xuefen LI, Xia ZHOU, Yanrui FENG, Lijing ZHU, Heyu ZHANG, Lisha SUN, Tiejun LI

DOI: 10.1631/jzus.B2400081 Downloaded: 269 Clicked: 506 Cited: 0 Commented: 0(p.) <Full Text>

Autophagy receptor-inspired chimeras: A novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation

Liwen WANG, Huimei LIU, Lanfang LI

DOI: 10.1631/jzus.B2300853 Downloaded: 453 Clicked: 688 Cited: 0 Commented: 0(p.) <Full Text>

EGCG as a therapeutic agent: a systematic review of recent advances and challenges in nanocarrier strategies

Chee Ning WONG, Yang Mooi LIM, Kai Bin LIEW, Yik-Ling CHEW, Ang-Lim CHUA, Siew-Keah LEE

DOI: 10.1631/jzus.B2400040 Downloaded: 503 Clicked: 626 Cited: 0 Commented: 0(p.) <Full Text>

Food-derived bioactive peptides: health benefits, structure-activity relationships, and translational prospects

Hongda CHEN, Jiabei SUN, Haolie FANG, Yuanyuan LIN, Han WU, Dongqiang LIN, Zhijian YANG, Quan ZHOU, Bingxiang ZHAO, Tianhua ZHOU, Jianping WU, Shanshan LI, Xiangrui LIU

DOI: 10.1631/jzus.B2400106 Downloaded: 354 Clicked: 488 Cited: 0 Commented: 0(p.) <Full Text>

Efficient genome editing in Medaka (Oryzias latipes) using a codon optimized SaCas9 system

Yuewen JIANG, Qihua PAN, Zhi WANG, Ke LU, Bilin XIA, Tiansheng CHEN

DOI: 10.1631/jzus.B2300899 Downloaded: 504 Clicked: 762 Cited: 0 Commented: 0(p.) <Full Text>

NRF2 nuclear translocation and interaction with DUSP1 may regulate osteogenic differentiation of murine mandibular osteoblasts stimulated by Pg-LPS

Xufei YU, Jiaqi BAO, Yingming WEI, Yuting YANG, Wenlin YUAN, Lili CHEN, Zhongxiu WANG

DOI: 10.1631/jzus.B2400203 Downloaded: 352 Clicked: 448 Cited: 0 Commented: 0(p.) <Full Text>

Potential role of FNDC5 in exercise-induced improvement of cognitive function

Ruobing ZHAO, Xuchang ZHOU, Dongxue WANG, Haifeng TANG, Guoxin NI

DOI: 10.1631/jzus.B2400016 Downloaded: 440 Clicked: 628 Cited: 0 Commented: 0(p.) <Full Text>

Residual hyperglycemia after successful treatment of a patient with severe copper sulfate poisoning

Ting LI, Yuanqiang LU

DOI: 10.1631/jzus.B2400305 Downloaded: 226 Clicked: 385 Cited: 0 Commented: 0(p.) <Full Text>

A case of cardiac arrest and spontaneous renal hemorrhage in a male patient with persistent eosinophilia: highlighting the importance of early diagnosis of eosinophilic granulomatosis with polyangiitis

Jinya LIN, Rending WANG, Yuanyuan ZHU, Weijia HUANG, Jie SUN

DOI: 10.1631/jzus.B2300940 Downloaded: 126 Clicked: 212 Cited: 0 Commented: 0(p.) <Full Text>

COMPERA 2.0 risk stratification in patients with severe aortic stenosis: implication for group 2 pulmonary hypertension

Zongye CAI, Xinrui QI, Dao ZHOU, Hanyi DAI, Abuduwufuer YIDILISI, Ming ZHONG, Lin DENG, Yuchao GUO, Jiaqi FAN, Qifeng ZHU, Yuxin HE, Cheng LI, Xianbao LIU, Jianan WANG

DOI: 10.1631/jzus.B2400057 Downloaded: 141 Clicked: 236 Cited: 0 Commented: 0(p.) <Full Text>

Future of PARP inhibitors in cancer treatment: overcoming resistance and enhancing efficacy with combination therapies

Muhammad SHOAIB, Zeeshan Ahmad BHUTTA, Ahsan JAVED, Muhammad Nabeel AMJAD, Wenzhu LI, Kyung-Chul CHOI, Wanxia PU

DOI: 10.1631/jzus.B2400146 Downloaded: 144 Clicked: 247 Cited: 0 Commented: 0(p.) <Full Text>

PICK1 modulates proliferation and migration of gastric cancer cells via regulating TLR4

Kaiqiang LI, Yimin YANG, Yaling WANG, Jing JIN, Qianni WANG, Lina PENG, Aibo XU, Xuling LUO, Wei YANG, Peng XU, Bingyu CHEN, Ke HAO, Zhen WANG

DOI: 10.1631/jzus.B2400167 Downloaded: 124 Clicked: 199 Cited: 0 Commented: 0(p.) <Full Text>

Potential effect of endothelial progenitor cells on pentylenetetrazole-induced seizures in rats: an evaluation of relevant long noncoding RNAs

Shimaa O. ALI, Nancy N. SHAHIN, Marwa M. SAFAR, Sherine M. RIZK

DOI: 10.1631/jzus.B2400242 Downloaded: 121 Clicked: 206 Cited: 0 Commented: 0(p.) <Full Text>

A novel bacterial strain for the removal of ammonia nitrogen from wastewater: Pseudomonas oleovorans QS-7

Hao QIU, Min LIAO, Xiaomei XIE, Xinyue LU, Feng YUAN, Zhe LUO, Chunlin FAN

DOI: 10.1631/jzus.B2400257 Downloaded: 135 Clicked: 269 Cited: 0 Commented: 0(p.) <Full Text>

From 2D to 3D: transforming malignant bone tumor research with advanced culture models

Zhengcheng HE, Haitao HUANG, Jiale FANG, Huiping LIU, Xudong YAO, Hongwei WU

DOI: 10.1631/jzus.B2400288 Downloaded: 143 Clicked: 221 Cited: 0 Commented: 0(p.) <Full Text>

Establishment of a standardized daily behavior collection and analysis system for brain disease models of rhesus and cynomolgus monkeys and its application in autism spectrum disorder

Xiaofeng REN,, Huimin WANG, Xiaoman LV, Yi ZHOU, Yingyin FAN, Yanjun YU, Christoph W. TURCK, Yuhui CHEN, Longbao LV, Yingzhou HU, Hao LI, Wenchao WANG, Dongdong QIN, Xiaoli FENG, Xintian HU

DOI: 10.1631/jzus.B2400294 Downloaded: 287 Clicked: 437 Cited: 0 Commented: 0(p.) <Full Text>   <PPT >  63

Chinese summary   <>  恒河猴和食蟹猴脑疾病模型的标准化日常行为采集和分析系统的建立及其在孤独症谱系障碍中的应用

任晓峰1,2,5,王慧敏3,吕小满4,周仪3,范颖尹1,2,5,余妍君1,2,5,Christoph W. TURCK1,2,陈雨慧3,吕龙宝1,胡英周1,2,李浩1,2,王文超1,2,秦冬冬4,冯晓丽3,胡新天1,2
1中国科学院昆明动物研究所模式动物表型与遗传研究国家重大科技基础设施(灵长类设施),遗传进化与动物模型全国重点实验室,国家非人灵长类实验动物资源库,中国昆明市,650107
2中国科学院昆明动物研究所云南省动物模型与人类疾病机理重点实验室,昆明动物研究所/香港中文大学生物资源与疾病分子机理联合实验室,中国昆明市,650201
3昆明医科大学基础医学院生理学系,中国昆明市,650500
4云南中医药大学中医药防治神经精神疾病重点实验室,中国昆明市,650500
5中国科学院大学,中国北京市,101408
摘要:复杂脑疾病严重危害人类健康,目前缺乏早期诊断生物标志物和有效的治疗方法。由于人类研究受到伦理的限制,猴模型的建立对解决这些问题至关重要。随着转基因技术的快速发展,一系列脑疾病,尤其是孤独症谱系障碍(ASD)的转基因猴模型已被成功建立。然而,要建立实用、有效的脑疾病模型,并将其应用于疾病机理和治疗研究中,目前还缺乏一个标准的工具,即脑疾病模型猴的日常行为采集和分析系统。因此,我们以行为表型的全面、定量研究为目标,针对模型构建中常用的恒河猴和食蟹猴,建立了一个标准的日常行为采集和分析系统,包括行为数据采集方法和猴日常行为目录(MDBE)。然后,我们以ASD为应用实例,参考广泛用于临床疾病和模型研究的《精神障碍诊断与统计手册》(第五版,修订版)(DSM-5-TR)中的ASD核心临床症状,基于MDBE建立了一个用于ASD猴模型核心临床症状定量评估的子行为目录(ASD猴核心行为目录(MCBE-ASD))。随后,我们通过实验数据证明了该系统的高度可重复性,并比较了不同恒河猴个体间行为模式的差异。

关键词组:猴日常行为目录;猴行为采集方法;恒河猴;食蟹猴;孤独症谱系障碍(ASD)



Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE