CLC number:
On-line Access: 2019-04-15
Received: 2018-04-29
Revision Accepted: 2018-07-02
Crosschecked: 2019-03-14
Cited: 0
Clicked: 2239
Leming Sun, Email author, Zhen Fan, Tao Yue, Jun Yin, Jianzhong Fu, Mingjun Zhang. Additive nanomanufacturing of lab-on-a-chip fluorescent peptide nanoparticle arrays for Alzheimers disease diagnosis[J]. Journal of Zhejiang University Science D, 2018, 1(3): 182-194.
@article{title="Additive nanomanufacturing of lab-on-a-chip fluorescent peptide nanoparticle arrays for Alzheimers disease diagnosis",
author="Leming Sun, Email author, Zhen Fan, Tao Yue, Jun Yin, Jianzhong Fu, Mingjun Zhang",
journal="Journal of Zhejiang University Science D",
volume="1",
number="3",
pages="182-194",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-018-0019-9"
}
%0 Journal Article
%T Additive nanomanufacturing of lab-on-a-chip fluorescent peptide nanoparticle arrays for Alzheimers disease diagnosis
%A Leming Sun
%A Email author
%A Zhen Fan
%A Tao Yue
%A Jun Yin
%A Jianzhong Fu
%A Mingjun Zhang
%J Journal of Zhejiang University SCIENCE D
%V 1
%N 3
%P 182-194
%@ 1869-1951
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-018-0019-9
TY - JOUR
T1 - Additive nanomanufacturing of lab-on-a-chip fluorescent peptide nanoparticle arrays for Alzheimers disease diagnosis
A1 - Leming Sun
A1 - Email author
A1 - Zhen Fan
A1 - Tao Yue
A1 - Jun Yin
A1 - Jianzhong Fu
A1 - Mingjun Zhang
J0 - Journal of Zhejiang University Science D
VL - 1
IS - 3
SP - 182
EP - 194
%@ 1869-1951
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-018-0019-9
Abstract: This paper proposes an additive nanomanufacturing approach to fabricate a personalized lab-on-a-chip fluorescent peptide nanoparticles (f-PNPs) array for simultaneous multi-biomarker detection that can be used in Alzheimers disease (AD) diagnosis. We will discuss optimization techniques for the additive nanomanufacturing process in terms of reliability, yield and manufacturing efficiency. One contribution of this paper lies in utilization of additive nanomanufacturing techniques to fabricate a patient-specific customize-designed lab-on-a-chip device for personalized AD diagnosis, which remains a major challenge for biomedical engineering. Through the integrated bio-design and bio-manufacturing process, doctors check-up and computer-aided customized design are integrated into the lab-on-a-chip array for patient-specific AD diagnosis. In addition, f-PNPs with targeting moieties for personalized AD biomarkers will be self-assembled onto the customized lab-on-a-chip through the additive nanomanufacturing process, which has not been done before. Another contribution of this research is the personalized lab-on-a-chip f-PNPs array for AD diagnosis utilizing limited human blood. Blood-based AD assessment has been described as the holy grail of early AD detection. This research created the computer-aided design, fabrication through additive nanomanufacturing, and validation of the f-PNPs array for AD diagnosis. This is a highly interdisciplinary research contributing to nanotechnology, biomaterials, and biomedical engineering for neurodegenerative disease. The conceptual work is preliminary with intent to introduce novel techniques to the application. Large-scale manufacturing based on the proposed framework requires extensive validation and optimization.
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