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Bio-Design and Manufacturing  2018 Vol.1 No.4 P.265-279

http://doi.org/10.1007/s42242-018-0029-7


A review on biocompatibility nature of hydrogels with 3D printing techniques, tissue engineering application and its future prospective


Author(s):  Jabran Saroia, Wang Yanen, Qinghua Wei, Kun Zhang, Tingli Lu, Bo Zhang

Affiliation(s):  Department of Industry Engineering, College of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, People’s Republic of China; more

Corresponding email(s):   wangyanen@nwpu.edu.cn

Key Words:  Hydrogels, Extra-molecular matrix (ECM), Biocompatibility, Bioprinting, Tissue engineering


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Jabran Saroia, Wang Yanen, Qinghua Wei, Kun Zhang, Tingli Lu, Bo Zhang. A review on biocompatibility nature of hydrogels with 3D printing techniques, tissue engineering application and its future prospective[J]. Journal of Zhejiang University Science D, 2018, 1(4): 265-279.

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Abstract: 
Recently, tissue engineering (TE) is one of the fast growing research fields due the accessibility of extra-molecular matrix (ECM) at cellular and molecular level with valuable potential prospective of hydrogels. The enhancement in the production of hydrogel-based cellular scaffolds with the structural composition of ECM has been accelerated with involvement of rapid prototyping techniques. Basically, the recreation of ECM has been derived from naturally existed or synthetic hydrogelbased polymers. The rapid utilization of hydrogels in TE puts forward the scope of bioprinting for the fabrication of the functional biological tissues, cartilage, skin and artificial organs. The main focus of the researchers is on biofabrication of the biomaterials with maintaining the biocompatibility, biodegradability and increasing growth efficiency. In this review, biological development in the structure and cross-linking connections of natural or synthetic hydrogels are discussed. The methods and design criteriathat influence the chemical and mechanical properties and interaction of seeding cells before and aftertheimplantationsarealsodemonstrated.Themethodologyofbioprintingtechniquesalongwithrecentdevelopmenthas alsobeenreviewed.Intheend,somecapabilitiesandshortcomingsarepointedoutforfurtherdevelopmentofhydrogels-based scaffolds and selection of bioprinting technology depending on their application.

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