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Bio-Design and Manufacturing  2021 Vol.4 No.1 P.44-59


3D printing of PEEKcHAp scaffold for medical bone implant

Author(s):  Bankole I. Oladapo, S. Abolfazl Zahedi, Sikiru O. Ismail, Francis T. Omigbodun, Oluwole K. Bowoto, Mattew A. Olawumi, Musa A. Muhammad

Affiliation(s):  School of Engineering and Sustainable Development, De Montfort University, Leicester, UK; more

Corresponding email(s):   Bankole.Oladapo@dmu.ac.uk, bioladapo@abuad.edu.ng

Key Words:  3D printing, PEEKcHAp biocomposite, Nanostructure, Bone implant, Composite morphing

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Bankole I. Oladapo, S. Abolfazl Zahedi, Sikiru O. Ismail, Francis T. Omigbodun, Oluwole K. Bowoto, Mattew A. Olawumi, Musa A. Muhammad . 3D printing of PEEKcHAp scaffold for medical bone implant[J]. Journal of Zhejiang University Science D, 2021, 4(1): 44-59.

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author="Bankole I. Oladapo, S. Abolfazl Zahedi, Sikiru O. Ismail, Francis T. Omigbodun, Oluwole K. Bowoto, Mattew A. Olawumi, Musa A. Muhammad ",
journal="Journal of Zhejiang University Science D",
publisher="Zhejiang University Press & Springer",

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%T 3D printing of PEEKcHAp scaffold for medical bone implant
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%A S. Abolfazl Zahedi
%A Sikiru O. Ismail
%A Francis T. Omigbodun
%A Oluwole K. Bowoto
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A1 - S. Abolfazl Zahedi
A1 - Sikiru O. Ismail
A1 - Francis T. Omigbodun
A1 - Oluwole K. Bowoto
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DOI - 10.1007/s42242-020-00098-0

The major drawback associated with PEEK implants is their biologically inert surface, which caused unsatisfactory cellular response and poor adhesion between the implants and surrounding soft tissues against proper bone growth. In this study, polyetheretherketone (PEEK) was incorporated with calcium hydroxyapatite (cHAp) to fabricate a PEEKcHAp biocomposite, using the fused deposition modeling (FDM) method and a surface treatment strategy to create microporous architectures onto the filaments of PEEK lattice scaffold. Also, nanostructure and morphological tests of the PEEKcHAp biocomposite were modeled and analyzed on the FDM-printed PEEKcHAp biocomposite sample to evaluate its mechanical and thermal strengths as well as in vitro cytotoxicity via a scanning electron microscope (SEM). A technique was used innovatively to create and investigate the porous nanostructure of the PEEK with controlled pore size and distribution to promote cell penetration and biological integration of the PEEKcHAp into the tissue. In vivo tests demonstrated that the surface-treated micropores facilitated the adhesion of newly regenerated soft tissues to form tight implanttissue interfacial bonding between the cHAp and PEEK. The results of the cell culture depicted that PEEKcHAp exhibited better cell proliferation attachment spreading and higher alkaline phosphatase activity than PEEK alone. Apatite islands formed on the PEEKcHAp composite after immersion in simulated body fluid of Dulbecco's modified Eagle medium (DMEM) for 14 days and grew continuously with more or extended periods. The microstructure treatment of the crystallinity of PEEK was comparatively and significantly different from the PEEKcHAp sample, indicating a better treatment of PEEKcHAp. The in vitro results obtained from the PEEKcHAp biocomposite material showed its biodegradability and performance suitability for bone implants. This study has potential applications in the field of biomedical engineering to strengthen the conceptual knowledge of FDM and medical implants fabricated from PEEKcHAp biocomposite materials.

英国德蒙福特大学Oladapo等 | 用于医用骨植入物的PEEK–cHAp支架的3D打印


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