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Bio-Design and Manufacturing  2021 Vol.4 No.2 P.243-257

http://doi.org/10.1007/s42242-020-00113-4


Reduced graphene oxide-grafted bovine serum albumin/bredigite nanocomposites with high mechanical properties and excellent osteogenic bioactivity for bone tissue engineering


Author(s):  Esfandyar Askari, Mohammad Rasouli, Seyedeh F. Darghiasi, Seyed M. Naghib, Yasser Zare & Kyong Y. Rhee

Affiliation(s):  Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology (IUST), P.O. Box 16846-13114, Tehran, Iran; more

Corresponding email(s):   rheeky@khu.ac.kr, naghib@iust.ac.ir

Key Words:  Bovine serum albumin (BSA), Reduced graphene oxide (rGO), Bredigite, Mechanical properties, Bone tissue engineering


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Esfandyar Askari, Mohammad Rasouli, Seyedeh F. Darghiasi, Seyed M. Naghib, Yasser Zare & Kyong Y. Rhee. Reduced graphene oxide-grafted bovine serum albumin/bredigite nanocomposites with high mechanical properties and excellent osteogenic bioactivity for bone tissue engineering[J]. Journal of Zhejiang University Science D, 2021, 4(2): 243-257.

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Abstract: 
The optimization of the scaffolds to provide a suitable matrix and accelerate the regeneration process is vital for bone tissue engineering. However, poor mechanical and biological characteristics remain the primary challenges that must be addressed. For example, although bredigite (Br) has shown great potential for application in bone tissue engineering, it easily fails in replacement. In the present work, these challenges are addressed by reinforcing the Br matrix with nanosheets of graphene oxide (rGO) that have been reduced by bovine serum albumin (BSA) in order to enhance the mechanical properties and biological behavior. The reduction of graphene oxide by BSA improves the water stability of the nanosheets and provides an electrostatic interaction between the BSA-rGO nanosheets and the Br particles. The high thermal conductivity of the BSA-rGO nanosheets decreases the porosity of the Br by transferring heat to the core of the tablet. Furthermore, the addition of BSA-rGO nanosheets into the Br matrix enhances the adhesion of G-292 cells on the surface of the tablets. These findings suggest that the tablet consisting of BSA-rGO-reinforced Br has encouraging potential for application in bone tissue engineering.

庆熙大学Rhee等 | 用于骨组织工程的具有高机械性能和优异成骨生物活性的还原氧化石墨烯接枝牛血清白蛋白/白硅钙石纳米复合材料

本研究论文聚焦用于骨组织工程的具有高机械性能和优异成骨生物活性的还原氧化石墨烯接枝牛血清白蛋白/白硅钙石纳米复合材料。支架的优化以提供合适的基质并加速再生过程对于骨组织工程至关重要。然而,较差的机械和生物学特性仍然是必须解决的主要挑战。例如,尽管白硅钙石(Br)在骨组织工程中显示出巨大的应用潜力,但它更换时很容易失效。在此研究中,这些挑战通过用已被牛血清白蛋白 (BSA) 还原的氧化石墨烯 (rGO) 纳米片增强Br基质来解决,以提高机械性能和生物性能。BSA对氧化石墨烯的还原提高了纳米片的水稳定性,并在 BSA-rGO 纳米片和Br颗粒之间提供了静电相互作用。BSA-rGO 纳米片的高导热性通过将热量传递到片剂的核心来降低 Br 的孔隙率。此外,将 BSA-rGO 纳米片添加到 Br 基质中可增强 G-292 细胞在片剂表面的粘附。这些发现表明,由 BSA-rGO 增强的 Br 组成的片剂在骨组织工程中具有令人鼓舞的应用潜力。

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