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Bio-Design and Manufacturing  2021 Vol.4 No.2 P.405-428

http://doi.org/10.1007/s42242-020-00117-0


3D printing biomimetic materials and structures for biomedical applications


Author(s):  Yizhen Zhu, Dylan Joralmon, Weitong Shan, Yiyu Chen, Jiahui Rong, Hanyu Zhao, Siqi Xiao & Xiangjia Li

Affiliation(s):  School for Engineering of Matter, Transport and Energy, Arizona State University, 501 E. Tyler Mall, Tempe, AZ 85287, USA; more

Corresponding email(s):   xiangjia.li@asu.edu

Key Words:  3D printing Bioprinting, Biomimetic material, Functional structures, Biomedical applications


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Yizhen Zhu, Dylan Joralmon, Weitong Shan, Yiyu Chen, Jiahui Rong, Hanyu Zhao, Siqi Xiao & Xiangjia Li. 3D printing biomimetic materials and structures for biomedical applications[J]. Journal of Zhejiang University Science D, 2021, 4(2): 405-428.

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Abstract: 
Over millions of years of evolution, nature has created organisms with overwhelming performances due to their unique materials and structures, providing us with valuable inspirations for the development of next-generation biomedical devices. As a promising new technology, 3D printing enables the fabrication of multiscale, multi-material, and multi-functional three-dimensional (3D) biomimetic materials and structures with high precision and great flexibility. The manufacturing challenges of biomedical devices with advanced biomimetic materials and structures for various applications were overcome with the flourishing development of 3D printing technologies. In this paper, the state-of-the-art additive manufacturing of biomimetic materials and structures in the field of biomedical engineering were overviewed. Various kinds of biomedical applications, including implants, lab-on-chip, medicine, microvascular network, and artificial organs and tissues, were respectively discussed. The technical challenges and limitations of biomimetic additive manufacturing in biomedical applications were further investigated, and the potential solutions and intriguing future technological developments of biomimetic 3D printing of biomedical devices were highlighted.

亚利桑那州立大学Xiangjia Li等 | 用于生物医学应用的3D打印仿生材料和结构

经过数百万年的演化,大自然以独特的材料和结构创造了具有压倒性性能的生物组织,这为我们开发下一代生物医学设备提供了宝贵的灵感。作为一项富有前景的新兴技术,3D打印能够高精度地灵活地制造出具有多尺度、多材料和多功能特性的三维(3D)仿生材料及结构。随着 3D 打印技术的蓬勃发展,我们得以利用各种先进的仿生材料和结构克服生物医学设备制造过程中的挑战。本文概述了生物医学工程领域中前沿仿生材料和增材制造技术的最新进展。其中包括植入物、片上实验室、药物、微血管网络以及人工器官和组织等生物医学应用。本文还进一步讨论了仿生增材制造在生物医学应用中所面临的技术挑战和局限性,并着重探讨了在开发生物医学设备过程中应用仿生 3D 打印技术的解决方案和未来技术发展趋势。

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