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Bio-Design and Manufacturing  2021 Vol.4 No.3 P.627-640

http://doi.org/10.1007/s42242-020-00124-1


Prospects for 3D bioprinting of organoids


Author(s):  Preety Rawal, Dinesh M. Tripathi, Seeram Ramakrishna & Savneet Kaur

Affiliation(s):  Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences (ILBS), D1, Vasant Kunj, New Delhi 110070, India; more

Corresponding email(s):   savykaur@gmail.com

Key Words:  Three-dimensional bioprinting, Bioink, Organoid, Microfluidics, Extracellular matrix (ECM), Biomaterial


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Preety Rawal, Dinesh M. Tripathi, Seeram Ramakrishna & Savneet Kaur. Prospects for 3D bioprinting of organoids[J]. Journal of Zhejiang University Science D, 2021, 4(3): 627-640.

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Abstract: 
Three-dimensional (3D) organoids derived from pluripotent or adult tissue stem cells seem to possess excellent potential for studying development and disease mechanisms alongside having a myriad of applications in regenerative therapies. However, lack of precise architectures and large-scale tissue sizes are some of the key limitations of current organoid technologies. 3D bioprinting of organoids has recently emerged to address some of these impediments. In this review, we discuss 3D bioprinting with respect to the use of bioinks and bioprinting methods and highlight recent studies that have shown success in bioprinting of stem cells and organoids. We also summarize the use of several vascularization strategies for the bioprinted organoids, that are critical for a complex tissue organization. To fully realize the translational applications of organoids in disease modeling and regenerative medicine, these areas in 3D bioprinting need to be appropriately harnessed and channelized.

印度肝脏与胆道科学研究所Savneet Kaur等 | 3D生物打印类器官的前景

本综述论文聚焦类器官生物制造的发展与应用前景。来自多能或成体组织干细胞的三维(3D)类器官在研究发育和疾病机制方面极具潜力,同时在再生疗法中有很多应用。然而,缺乏精确的结构和大尺寸组织的制造方法,是当前类器官技术遇到的关键局限。最近出现的类器官3D生物打印技术,可以尝试解决其中一些障碍。本综述讨论了3D生物打印与生物墨水和打印方法的使用,并强调了最近在干细胞和类器官生物打印方面取得成功的研究。总结了生物打印类器官的几种血管化策略的使用,这些策略对复杂的组织构建至关重要。为了充分实现类器官在疾病模型构建和再生医学中的转化应用,3D生物打印技术应在这些方面被更好地利用。

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