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Received: 2021-07-03

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Bio-Design and Manufacturing  2022 Vol.5 No.3 P.556-579

http://doi.org/10.1007/s42242-022-00182-7


Application of additively manufactured 3D scaffolds for bone cancer treatment: a review


Author(s):  Yanhao Hou, Weiguang Wang & Paulo Bartolo

Affiliation(s):  Department of Mechanical, Aerospace and Civil Engineering, School of Engineering, Faculty of Science and Engineering, The University of Manchester, Manchester M13 9PL, UK; more

Corresponding email(s):   weiguang.wang@manchester.ac.uk, paulojorge.dasilvabartolo@manchester.ac.uk, pbartolo@ntu.edu.sg

Key Words:  Additive manufacturing, Biomanufacturing, Bone cancer, Implants, Tissue engineering


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Yanhao Hou, Weiguang Wang & Paulo Bartolo. Application of additively manufactured 3D scaffolds for bone cancer treatment: a review[J]. Journal of Zhejiang University Science D, 2022, 5(3): 556-579.

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Abstract: 
bone cancer is a critical health problem on a global scale, and the associated huge clinical and economic burdens are still rising. Although many clinical approaches are currently used for bone cancer treatment, these methods usually affect the normal body functions and thus present significant limitations. Meanwhile, advanced materials and additive manufacturing have opened up promising avenues for the development of new strategies targeting both bone cancer treatment and post-treatment bone regeneration. This paper presents a comprehensive review of bone cancer and its current treatment methods, particularly focusing on a number of advanced strategies such as scaffolds based on advanced functional materials, drug-loaded scaffolds, and scaffolds for photothermal/magnetothermal therapy. Finally, the main research challenges and future perspectives are elaborated.

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