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Bio-Design and Manufacturing  2016 Vol.-1 No.-1 P.

http://doi.org/10.1007/s42242-023-00031-X


Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species


Author(s):  Xinshuo Huang, Baoming Liang, Shantao Zheng, Feifei Wu, Mengyi He, Shuang Huang, Jingbo Yang, Qiangqiang Ouyang, Fanmao Liu, Jing Liu, Hui-jiuan Chen, Xi Xie

Affiliation(s):  State Key Laboratory of Optoelectronic Materials and Technologies, School of Electronics and Information Technology, Guangdong Province Key Laboratory of Display Material and Technology, Sun Yat-sen University, Guangzhou 510006, China; more

Corresponding email(s):   chenhuix5@mail.sysu.edu.cn, xiexi27@mail.sysu.edu.cn

Key Words:  Microarrow sensor array, glucose sensing, reactive oxygen species sensing, integrated system, continuous monitoring


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Xinshuo Huang,Baoming Liang,Shantao Zheng,Feifei Wu,Mengyi He,Shuang Huang,Jingbo Yang,Qiangqiang Ouyang,Fanmao Liu,Jing Liu,Hui-jiuan Chen, Xi Xie. Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species[J]. Journal of Zhejiang University Science D, 2016, -1(-1): .

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A1 - Xinshuo Huang
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A1 - Feifei Wu
A1 - Mengyi He
A1 - Shuang Huang
A1 - Jingbo Yang
A1 - Qiangqiang Ouyang
A1 - Fanmao Liu
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A1 - Hui-jiuan Chen
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Abstract: 
Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in vivo. Continuous glucose monitoring based on implantable electrodes could induce pain and potential tissue inflammation, and the presence of reactive oxygen species (ROS) due to inflammation may affect glucose detection. Microneedle technology is less invasive, yet microneedle adhesion with skin tissue is limited. In this work, we developed a microarrow sensor array (MASA), which provided enhanced skin surface adhesion and enabled simultaneous detection of glucose and H2O2 (representative of ROS) in interstitial fluid in vivo. The microarrows fabricated via laser micromachining were modified with functional coating and integrated into a patch of a three-dimensional (3D) microneedle array. Due to the arrow tip mechanically interlocking with the tissue, the microarrow array could better adhere to the skin surface after penetration into skin. The MASA was demonstrated to provide continuous in vivo monitoring of glucose and H2O2 concentrations, with the detection of H2O2 providing a valuable reference for assessing the inflammation state. Finally, the MASA was integrated into a monitoring system using custom circuitry. This work provides a promising tool for the stable and reliable monitoring of blood glucose in diabetic patients.

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