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Bio-Design and Manufacturing  2023 Vol.6 No.2 P.174-188

http://doi.org/10.1007/s42242-023-00239-1


Numerical simulation and printability analysis of fused deposition modeling with dual-temperature control


Author(s):  Xiaodan Huo, Bin Zhang, Qianglong Han, Yong Huang & Jun Yin

Affiliation(s):  The State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310028, China; more

Corresponding email(s):   yongh@ufl.edu, junyin@zju.edu.cn

Key Words:  Fused deposition modeling (FDM), Dual-temperature control, Filament deposition, Printing resolution, Viscosity


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Xiaodan Huo, Bin Zhang, Qianglong Han, Yong Huang & Jun Yin . Numerical simulation and printability analysis of fused deposition modeling with dual-temperature control[J]. Journal of Zhejiang University Science D, 2023, 6(2): 174-188.

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Abstract: 
Ideal tissue engineering scaffolds need interconnected pores and high porosity to enable cell survival, migration, proliferation, and differentiation. However, obtaining a high-resolution structure is difficult with traditional one-temperature control fused deposition modeling (FDM). In this study, we propose a dual-temperature control method to improve printability. A numerical model is developed in which the viscosity is a function of temperature and shear rate to study the influence of two different temperature control modes. Quantitative tests are used to assess filament formation and shape fidelity, including one-dimensional filament printing, deposition at corners, fusion, and collapse. By using dual-temperature control, the width of the deposited poly(ε-caprolactone) filament is reduced to 50 μm. The comparative results of both the experimental method and numerical simulation suggest that the dual-temperature control FDM can manufacture spatially arranged constructs and presents a promising application in tissue engineering.

浙江大学尹俊等 | 双级温控熔融沉积(FDM)打印的数值模拟和可打印性分析

本研究论文聚焦于双级温控熔融沉积打印的数值模拟和可打印性分析。理想的组织工程支架应具有相互连接的孔结构和高孔隙率以确保细胞的渗透、营养物质的充分扩散以及代谢废物的排出。支架的孔隙必须足够大以允许细胞迁移到结构中;同时,孔隙又必须足够小以获得尽可能大的比表面积,促进细胞与支架之间的粘附。因此精确调控支架孔隙率及孔隙结构对于制备理想的组织工程支架具有重要的意义。传统的FDM打印的聚己内酯(PCL)支架的丝径一般在200 μm以上,比细胞尺寸(10 μm)要大得多。因此,如何提高分辨率和形状保真度是制备组织工程支架过程中亟待解决的难题。
鉴于此,浙江大学机械工程学院尹俊研究员和美国佛罗里达大学机械与航空航天工程系Yong Huang教授提出了一种双级温控工艺,通过在料筒处施加较高的加热温度提高熔体流动性,同时在针头处施加较低的温度提高挤出材料的成形性,从而制备高精度(约50 μm)和高形状保真度的支架结构,极大地拓展了熔融沉积打印在组织工程中的应用前景。相关成果以“Numerical simulation and printability analysis of fused deposition modeling with dual-temperature control”为题发表于Bio-Design and Manufacturing上,浙江大学机械工程学院霍小丹博士生与张斌研究员为共同第一作者,浙江大学机械工程学院流体动力基础件与机电系统全国重点实验室为第一单位。

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