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On-line Access: 2024-06-17
Received: 2024-06-13
Revision Accepted: 2024-04-01
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Flexible, high-density, laminated ECoG electrode array for high spatiotemporal resolution foci diagnostic localization of refractory epilepsy
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Yafeng Liu, Zhouheng Wang, Yang Jiao, Ying Chen, Guangyuan Xu, Yinji Ma & Xue Feng. Flexible, high-density, laminated ECoG electrode array for high spatiotemporal resolution foci diagnostic localization of refractory epilepsy[J]. Journal of Zhejiang University Science D, 2024, 7(4): 388-398.
@article{title="Flexible, high-density, laminated ECoG electrode array for high
spatiotemporal resolution foci diagnostic localization of refractory
epilepsy",
author="Yafeng Liu, Zhouheng Wang, Yang Jiao, Ying Chen, Guangyuan Xu, Yinji Ma & Xue Feng",
journal="Journal of Zhejiang University Science D",
volume="7",
number="4",
pages="388-398",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-024-00278-2"
}
%0 Journal Article
%T Flexible, high-density, laminated ECoG electrode array for high
spatiotemporal resolution foci diagnostic localization of refractory
epilepsy
%A Yafeng Liu
%A Zhouheng Wang
%A Yang Jiao
%A Ying Chen
%A Guangyuan Xu
%A Yinji Ma & Xue Feng
%J Journal of Zhejiang University SCIENCE D
%V 7
%N 4
%P 388-398
%@ 1869-1951
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-024-00278-2
TY - JOUR
T1 - Flexible, high-density, laminated ECoG electrode array for high
spatiotemporal resolution foci diagnostic localization of refractory
epilepsy
A1 - Yafeng Liu
A1 - Zhouheng Wang
A1 - Yang Jiao
A1 - Ying Chen
A1 - Guangyuan Xu
A1 - Yinji Ma & Xue Feng
J0 - Journal of Zhejiang University Science D
VL - 7
IS - 4
SP - 388
EP - 398
%@ 1869-1951
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-024-00278-2
Abstract: High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus
diagnostic localization, as the spatial scale of some pathologic signals is at the submillimeter or micrometer level. This entails
connecting hundreds or thousands of electrode wires on a limited surface. This study reported a class of flexible, ultrathin, highdensity electrocorticogram (ECoG) electrode arrays. The challenge of a large number of wiring arrangements was overcome
by a laminated structure design and processing technology improvement. The flexible, ultrathin, high-density ECoG electrode
array was conformably attached to the cortex for reliable, high spatial resolution electrophysiologic recordings. The minimum
spacing between electrodes was 15μm, comparable to the diameter of a single neuron. Eight hundred electrodes were prepared
with an electrode density of 4444 mm−2. In focal epilepsy surgery, the flexible, high-density, laminated ECoG electrode array
with 36 electrodes was applied to collect epileptic spike waves in rabbits, improving the positioning accuracy of epilepsy lesions
from the centimeter to the submillimeter level. The flexible, high-density, laminated ECoG electrode array has potential clinical
applications in intractable epilepsy and other neurologic diseases requiring high-precision electroencephalogram acquisition.
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