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Hydroxy-α-sanshool–loaded adipose-targeted mesoporous silica nanoparticles induce white adipose browning and reduce obesity by activating TRPV1
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zQing Zhang, Chengxun He, Juan Guo, Dandan Tang, Die Qian, Chuan Zheng, Chunjie Wu, Wei Peng. Hydroxy-α-sanshool–loaded adipose-targeted mesoporous silica nanoparticles induce white adipose browning and reduce obesity by activating TRPV1[J]. Journal of Zhejiang University Science D, 2016, -1(-1): .
@article{title="Hydroxy-α-sanshool–loaded adipose-targeted mesoporous silica
nanoparticles induce white adipose browning and reduce obesity by
activating TRPV1",
author="zQing Zhang, Chengxun He, Juan Guo, Dandan Tang, Die Qian, Chuan Zheng, Chunjie Wu, Wei Peng",
journal="Journal of Zhejiang University Science D",
volume="-1",
number="-1",
pages="",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400248"
}
%0 Journal Article
%T Hydroxy-α-sanshool–loaded adipose-targeted mesoporous silica
nanoparticles induce white adipose browning and reduce obesity by
activating TRPV1
%A zQing Zhang
%A Chengxun He
%A Juan Guo
%A Dandan Tang
%A Die Qian
%A Chuan Zheng
%A Chunjie Wu
%A Wei Peng
%J Journal of Zhejiang University SCIENCE D
%V -1
%N -1
%P
%@ 1869-1951
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400248
TY - JOUR
T1 - Hydroxy-α-sanshool–loaded adipose-targeted mesoporous silica
nanoparticles induce white adipose browning and reduce obesity by
activating TRPV1
A1 - zQing Zhang
A1 - Chengxun He
A1 - Juan Guo
A1 - Dandan Tang
A1 - Die Qian
A1 - Chuan Zheng
A1 - Chunjie Wu
A1 - Wei Peng
J0 - Journal of Zhejiang University Science D
VL - -1
IS - -1
SP -
EP -
%@ 1869-1951
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400248
Abstract: Obesity has become a global threat to health, and however the available drugs for treating obesity are limited. We investi‐
gated the anti-obesity effect of hydroxy-α-sanshool (HAS), an amide derived from the fruit of Zanthoxylum bungeanum, which
promotes the management of obesity by triggering the browning of white adipose tissue (WAT) targeting the membrane re‐
ceptor of TRPV1. However, HAS easily undergoes configuration transformation and oxidative degradation. Mesoporous
silica nanoparticles (MSNs) are widely used in drug delivery systems because of their large specific surface area and pore
volume. Furthermore, the short peptide CKGGRAKDC or adipose-targeting sequence (ATS) binds specifically to prohibitin
on the surface of WAT cells and can be used to modify MSNs to enhance adipocyte targetability. Therefore, HAS-loaded
adipose-targeted MSNs (MSN-ATS) were developed to enhance the adipocyte targetability, safety and efficacy of HAS, and
tested on mature 3T3-L1 cells and obese mouse models. MSNs-ATS showed higher specificity for adipocyte targetability
without obvious toxicity. HAS-loaded MSNs-ATS showed anti-obesity effects superior to those of HAS alone. In conclu‐
sion, we successfully developed adipocyte-targeted, HAS-loaded MSNs with good safety and anti-obesity effects.
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