Similar articles

Abstract: This study attempts to further clarify the potential effects of maternal high-fat (HF) diet on glucose homeostasis in dams and young adult male rat offspring. Female rats were divided into control (CON dams) and HF (HF dams) diet groups, which received the diet 4 weeks prior to and through pregnancy and lactation periods. Blood samples were taken to determine metabolic parameters, then an intraperitoneal glucose tolerance test (IPGTT) was performed. Maternal HF diet increased intra-abdominal fat mass and plasma corticosterone level, but decreased leptin concentration in dams. In HF offspring intra-abdominal fat mass, plasma leptin, and corticosterone levels decreased. Following IPGTT, the plasma insulin level of HF dams was higher than the controls. In HF offspring plasma insulin level was not significantly different from the controls, but a steeper decrease of their plasma glucose concentration was observed.

母代高脂饮食反向影响母鼠和子代成年雄性大鼠的胰岛素敏感度

[1]Bellisario, V., Berry, A., Capoccia, S., et al., 2014. Gender-dependent resiliency to stressful and metabolic challenges following prenatal exposure to high-fat diet in the p66^Shc−/− mouse. Behav. Neurosci., 8:285.

[2]Cerf, M.E., Chapman, C.S., Louw, J., 2012. High-fat programming of hyperglycemia, hyperinsulinemia, insulin resistance, hyperleptinemia, and altered islet architecture in 3-month-old Wistar rats. ISRN Endocrinol., 2012:627270.

[3]Clegg, D.J., Gotoh, K., Kemp, C., et al., 2011. Consumption of a high-fat diet induces central insulin resistance independent of adiposity. Physiol. Behav., 103(1):10-16.

[4]Desai, M., Jellyman, J.K., Han, G., et al., 2014. Rat maternal obesity and high fat diet program offspring metabolic syndrome. Am. J. Obstet., Gynecol., 211(3):237.e1-237.e13.

[5]Innis, S.M., 2005. Essential fatty acid transfer and fetal development. Placenta, 26(Suppl. A):S70-S75.

[6]Jacobs, S., Teixeira, D.S., Guilherme, C., et al., 2014. The impact of maternal consumption of cafeteria diet on reproductive function in the offspring. Physiol. Behav., 129(22):280-286.

[7]Kabaran, S., Besler, H.T., 2015. Do fatty acids affect fetal programming? J. Health Popul. Nutr., 33:14.

[8]Miotto, P.M., Castelli, L.M., Amoye, F., et al., 2013. Maternal high fat feeding does not have long-lasting effects on body composition and bone health in female and male Wistar rat offspring at young adulthood. Molecules, 18(12):15094-15109.

[9]Mueller, W.M., Gregoire, F.M., Stanhope, K.L., et al., 1998. Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinology, 139(2):551-558.

[10]Rostamkhani, F., Zardooz, H., Zahediasl, S., et al., 2012. Comparison of the effects of acute and chronic psychological stress on metabolic features in rats. J. Zhejiang Univ.-Sci. B (Biomed. & Biotechnol.), 13(11):904-912.

[11]Srinivasan, M., Katewa, S.D., Palaniyappan, A., et al., 2006. Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood. Am. J. Physiol. Endocrinol. Metab., 291(4):E792-E799.

[12]Stuebe, A.M., Rich-Edwards, J.W., 2009. The reset hypothesis: lactation and maternal metabolism. Am. J. Perinatol., 26(1):81-88.

[13]Sullivan, E.L., Riper, K.M., Lockard, R., et al., 2015. Maternal high-fat diet programming of the neuroendocrine system and behavior. Horm. Behav., 76:153-161.

[14]Tannenbaum, B.M., Brindley, D.N., Tannenbaum, G.S., 1997. High-fat feeding alters both basal and stress-induced hypothalamic-pituitary-adrenal activity in the rat. Am. J. Physiol. Endocrinol. Metab., 273(6):E1168-E1177.

[15]Tuohetimulati, G., Uchida, T., Toyofuku, Y., et al., 2012. Effect of maternal high-fat diet on pancreatic beta cells of the offspring. Diabetol. Int., 3(4):217-223.