CLC number: TQ018
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
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LU Xiang-hong, REN Qi-long, WU Ping-dong. Mathematical model of the dynamics of countercurrent chromatography[J]. Journal of Zhejiang University Science A, 2002, 3(2): 151-156.
@article{title="Mathematical model of the dynamics of countercurrent chromatography",
author="LU Xiang-hong, REN Qi-long, WU Ping-dong",
journal="Journal of Zhejiang University Science A",
volume="3",
number="2",
pages="151-156",
year="2002",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2002.0151"
}
%0 Journal Article
%T Mathematical model of the dynamics of countercurrent chromatography
%A LU Xiang-hong
%A REN Qi-long
%A WU Ping-dong
%J Journal of Zhejiang University SCIENCE A
%V 3
%N 2
%P 151-156
%@ 1869-1951
%D 2002
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2002.0151
TY - JOUR
T1 - Mathematical model of the dynamics of countercurrent chromatography
A1 - LU Xiang-hong
A1 - REN Qi-long
A1 - WU Ping-dong
J0 - Journal of Zhejiang University Science A
VL - 3
IS - 2
SP - 151
EP - 156
%@ 1869-1951
Y1 - 2002
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2002.0151
Abstract: A mathematical model of the dynamic behavior of countercurrent chromatography was proposed, and the model parameters, including the partition coefficient, the axial dispersion coefficient, the intraparticle diffusion coefficient and the external mass ransfer coefficient were calculated by the method of chromatogram moment analysis. Comparison of the experimental chromatograms of caffeine and theophylline determined in this work with the simulated curves computed by the proposed model showed fairly good agreement. Further, the difference between the average identified the partition coefficients by chromatogram moment analysis and the experimental values was small also, and the relationship between the external mass transfer rate and the linear velocity was similar to that obtained with solid-liquid chromatography.
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