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Journal of Zhejiang University SCIENCE A 2002 Vol.3 No.5 P.627-631


Study on the serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with Helicobacter pylori Infection

Author(s):  WU Qin-dong, ZHU Yong-liang, SHI Yi-hai

Affiliation(s):  Department of Gastroenterology, Second Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   wuqingdon@hzcnc.com

Key Words:  Helicobacter pylori, sICAM-1, Serum, Enzyme-linked immunosorbent assay (ELISA)

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WU Qin-dong, ZHU Yong-liang, SHI Yi-hai. Study on the serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with Helicobacter pylori Infection[J]. Journal of Zhejiang University Science A, 2002, 3(5): 627-631.

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author="WU Qin-dong, ZHU Yong-liang, SHI Yi-hai",
journal="Journal of Zhejiang University Science A",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Study on the serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with Helicobacter pylori Infection
%A WU Qin-dong
%A ZHU Yong-liang
%A SHI Yi-hai
%J Journal of Zhejiang University SCIENCE A
%V 3
%N 5
%P 627-631
%@ 1869-1951
%D 2002
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2002.0627

T1 - Study on the serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with Helicobacter pylori Infection
A1 - WU Qin-dong
A1 - ZHU Yong-liang
A1 - SHI Yi-hai
J0 - Journal of Zhejiang University Science A
VL - 3
IS - 5
SP - 627
EP - 631
%@ 1869-1951
Y1 - 2002
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2002.0627

Objective: To evaluate the interaction between serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and Helicobacter pylori (H. pylori) infection in patients with chronic gastritis and peptic ulcer. Methods: The serum levels of sICAM-1 in 205 patients with chronic gastric diseases were detected by ELISA method and the status of H. pylori was determined by histologic examination, RUT, 14C - UBT, and serology. The sera obtained from 18 healthy volunteers served as controls. Results: The serum levels of sICAM-1 were significantly higher in patients with H. pylori positive than those of H. pylori negative (889.43±32.52 ng/ml vs. 747.07±30.45 ng/ml, P<0.05). The serum levels of sICAM-1 in patients with mild, moderate and severe infection of H. pylori were 841.68±72.36 ng/ml, 905.43±37.59 ng/ml and 1012.54±49.34 ng/ml, respectively (P<0.05). The serum levels of sICAM-1 proved to be significantly correlated with the density of H. pylori colonization in gastric mucosa (rs=0.316, P<0.001). The serum levels of sICAM-1 in patients with chronic gastritis and peptic ulcer were significantly higher than those in healthy controls (P<0.05). Conclusions: These results indicated that H. pylori infection up-regulates the expression of sICAM-1.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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