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Journal of Zhejiang University SCIENCE A 2002 Vol.3 No.5 P.627-631

http://doi.org/10.1631/jzus.2002.0627


Study on the serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with Helicobacter pylori Infection


Author(s):  WU Qin-dong, ZHU Yong-liang, SHI Yi-hai

Affiliation(s):  Department of Gastroenterology, Second Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   wuqingdon@hzcnc.com

Key Words:  Helicobacter pylori, sICAM-1, Serum, Enzyme-linked immunosorbent assay (ELISA)


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WU Qin-dong, ZHU Yong-liang, SHI Yi-hai. Study on the serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with Helicobacter pylori Infection[J]. Journal of Zhejiang University Science A, 2002, 3(5): 627-631.

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author="WU Qin-dong, ZHU Yong-liang, SHI Yi-hai",
journal="Journal of Zhejiang University Science A",
volume="3",
number="5",
pages="627-631",
year="2002",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2002.0627"
}

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%T Study on the serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with Helicobacter pylori Infection
%A WU Qin-dong
%A ZHU Yong-liang
%A SHI Yi-hai
%J Journal of Zhejiang University SCIENCE A
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2002.0627

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T1 - Study on the serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with Helicobacter pylori Infection
A1 - WU Qin-dong
A1 - ZHU Yong-liang
A1 - SHI Yi-hai
J0 - Journal of Zhejiang University Science A
VL - 3
IS - 5
SP - 627
EP - 631
%@ 1869-1951
Y1 - 2002
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2002.0627


Abstract: 
Objective: To evaluate the interaction between serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and Helicobacter pylori (H. pylori) infection in patients with chronic gastritis and peptic ulcer. Methods: The serum levels of sICAM-1 in 205 patients with chronic gastric diseases were detected by ELISA method and the status of H. pylori was determined by histologic examination, RUT, 14C - UBT, and serology. The sera obtained from 18 healthy volunteers served as controls. Results: The serum levels of sICAM-1 were significantly higher in patients with H. pylori positive than those of H. pylori negative (889.43±32.52 ng/ml vs. 747.07±30.45 ng/ml, P<0.05). The serum levels of sICAM-1 in patients with mild, moderate and severe infection of H. pylori were 841.68±72.36 ng/ml, 905.43±37.59 ng/ml and 1012.54±49.34 ng/ml, respectively (P<0.05). The serum levels of sICAM-1 proved to be significantly correlated with the density of H. pylori colonization in gastric mucosa (rs=0.316, P<0.001). The serum levels of sICAM-1 in patients with chronic gastritis and peptic ulcer were significantly higher than those in healthy controls (P<0.05). Conclusions: These results indicated that H. pylori infection up-regulates the expression of sICAM-1.

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Reference

[1] Afifi, M.A., Tawfeek, G.M., Abdel Aziz, S.S., Abdel Aaty, H.A., 2000. Assessment of the role of soluble intracellular adhesion molecule-1(sICAM-1) in the pathogenesis and as a marker of disease severity in different stages of human schistosomiasis and toxoplasmosis. J. Egypt Soc Parasitol, 30(2):537-45

[2] Archimandritis, A., Sougioultzis, S., Foukas, P. G., Tzivras, M., Davaris, P., Moutsopoulos, H. M., 2000. Expression of HLA-DR, costimulatory molecules B7-1, B7-2, intercellular adhesion molecule-1 (ICAM-1) and Fas ligand (FasL) on gastric epithelial cells in Helicobacter pylori gastritis; influence of H. pylori eradication. Clin Exp Immunol., 119(3): 464-471.

[3] Bayerdorffer, E., Neubauer, A., Rudolph, B., Thiede, C., Lehn, N., Eidt, S., Stole, M., 1995. Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue after cure of Helicobacter pylori infection. Lancet, 345:1591-1594.

[4] Cutler, A. F., Havstad, S., Ma, C. K., Blaser, M. J., Perez-Perez, G. I., Schubert, T. T., 1995. Accuracy of invasive and noninvasive tests to diagnose H. pylori infection. Gastroenterol,109:136-141.

[5] Dooley, C. P., Cochen, H., Fitzgibbons, P. L., Bauer, M., Appleman, M. D., Perez-Perez, G. I., Blaser, M.J., 1989. Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N Engl. J. Med., 321:1562-1566.

[6] Egerer, K., Feist, E., Rohr, U., Pruss, A., Burmester, G.R., Dorner, T., 2000. Increased serum soluble CD14, ICAM-1 and E-selecting correlate with disease activity and prognosis in systemic lupus erythematosus. Lupus; 9(8):614-621.

[7] El Kaissouni, J., Bene, M.C., Faure, G.C., 1998. Activation of epithelial cells in gastritis. Digestion, 59(1):53-59.

[8] Fonsatti, E., Altomonte, M., Coral, S., Cattarossi, I., Nicotra, M. R., Gasparollo, A., Natali, P. G., Maio, M., 1997. Tumor derived interleukin 1α (IL-1α) up-regulates the release of soluble intercellular adhesion molecule-1 (sICAM-1) by endothelial cells. Br. J. Cancer, 76:1255-1261.

[9] Gearing, A. J. H., Newman, W., 1993. Circulating adhesion molecules in disease. Immunol Today, 14:506-512.

[10] Genta, R. M., Dixon, M. F., 1995. The Sydney System revisited: The Houston International Gastritis Workshop. Am J Gastroenterol, 90: 1039-1041.

[11] Graham, D. Y., Lew, G. M., Klein, P. D., Evans, D. G., Evans, D. Jr., Saeed, Z. A., Malaty, H.M., 1992. Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer: a randomized, controlled study. Ann Intern Med, 116:705-708.

[12] Higuchi, K., Arakawa, T., Uchida, T., Nakagawa, K., Nakamura, S., Matsumoto, T., Fukuda, T., Kobayashi, K., Kuroki, T., 1997. In situ expression of cell adhesion molecules in chronic gastritis with Helicobacter pylori infection. J Clin Gastroenterol, 25 Suppl 1:S215-221.

[13] Kaihara, A., Iwagaki, H., Gouchi, A., Hizuta, A., Isozaki, H., Takakura, N., Tanaka, N., 1998. Soluble intercellular adhesion molecule-1 and natural killer cell activity in gastric cancer patients. Res Commun Mol Pathol Pharmacol, 100:283-300.

[14] Kozol, R., Domanowski, A., Jaszewski, R., Czanko, R., McCurdy, B., Prasad, M., Fromm, B., Calzada, R., 1991. Neutrophil chemotaxis in gastric mucosa: a signal-to-response comparison. Dig Dis Sci, 36: 1277-1280.

[15] Mulligan, M. S., Johnson, K. J., Todd, R. F., Zssekutz, T. B., Miyasaka, M., Tamatani, T., Smith, C. W., Anderson, D. C., Ward, P. A., 1993. Requirements for leukocyte adhesion molecules in nephrotoxic nephritis. J Clin Invest, 91:577-587.

[16] Nakae, H., Endo, S., Inada, K., Takakuwa, T., Kasai, T., 1996. Changes in adhesion molecule levels in sepsis. Res Commun Molpathol Pharmacol, 91(3):329-938.

[17] Rothlein, R., Mainolfi, E. A., Czajkowski, M., Marlin, S. D., 1991. A form of circulating ICAM-1 in human serum. J Immunol, 147:3788-3793.

[18] Wagrowska-Danilewicz, M., Danilewicz, M., 1998. Intercellular adhesion molecule-1 (ICAM-1), leucocyte function-associated antigen-1 (LFA-1) and leucocyte infiltration in proliferative human glomerulonephritis. Acta Histochem, 100(2):201-215.

[19] Yang, S.S., Tsai, G., Wu, C.H., Chen, D.S., 1996. Circulating soluble intercellular adhesion molecule-1 in type C viral hepatitis. Hepatogastroenterolog, 43(9):575-581.

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