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CLC number: R978.2; Q71

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Received: 2004-07-10

Revision Accepted: 2004-08-03

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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.1 P.33-37

http://doi.org/10.1631/jzus.2005.B0033


Increased expression of aquaporin-4 in human traumatic brain injury and brain tumors


Author(s):  HU Hua, YAO Hong-tian, ZHANG Wei-ping, ZHANG Lei, DING Wei, ZHANG Shi-hong, CHEN Zhong, WEI Er-qing

Affiliation(s):  Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   weieq2001@yahoo.com

Key Words:  Aquaporin-4 (AQP4), Traumatic brain injury, Astrocytoma, Ganglioglioma, Metastatic adenocarcinoma, Brain edema


HU Hua, YAO Hong-tian, ZHANG Wei-ping, ZHANG Lei, DING Wei, ZHANG Shi-hong, CHEN Zhong, WEI Er-qing. Increased expression of aquaporin-4 in human traumatic brain injury and brain tumors[J]. Journal of Zhejiang University Science B, 2005, 6(1): 33-37.

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author="HU Hua, YAO Hong-tian, ZHANG Wei-ping, ZHANG Lei, DING Wei, ZHANG Shi-hong, CHEN Zhong, WEI Er-qing",
journal="Journal of Zhejiang University Science B",
volume="6",
number="1",
pages="33-37",
year="2005",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2005.B0033"
}

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%T Increased expression of aquaporin-4 in human traumatic brain injury and brain tumors
%A HU Hua
%A YAO Hong-tian
%A ZHANG Wei-ping
%A ZHANG Lei
%A DING Wei
%A ZHANG Shi-hong
%A CHEN Zhong
%A WEI Er-qing
%J Journal of Zhejiang University SCIENCE B
%V 6
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%@ 1673-1581
%D 2005
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B0033

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T1 - Increased expression of aquaporin-4 in human traumatic brain injury and brain tumors
A1 - HU Hua
A1 - YAO Hong-tian
A1 - ZHANG Wei-ping
A1 - ZHANG Lei
A1 - DING Wei
A1 - ZHANG Shi-hong
A1 - CHEN Zhong
A1 - WEI Er-qing
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 1
SP - 33
EP - 37
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B0033


Abstract: 
Objective: To characterize the expression of aquaporin-4 (AQP4), one of the aquaporins (AQPs), in human brain specimens from patients with traumatic brain injury or brain tumors. Methods: Nineteen human brain specimens were obtained from the patients with traumatic brain injury, brain tumors, benign meningioma or early stage hemorrhagic stroke. MRI or CT imaging was used to assess brain edema. Hematoxylin and eosin staining were used to evaluate cell damage. Immunohistochemistry was used to detect the AQP4 expression. Results: AQP4 expression was increased from 15 h to at least 8 d after injury. AQP4 immunoreactivity was strong around astrocytomas, ganglioglioma and metastatic adenocarcinoma. However, AQP4 immunoreactivity was only found in the centers of astrocytomas and ganglioglioma, but not in metastatic adenocarcinoma derived from lung. Conclusion: AQP4 expression increases in human brains after traumatic brain injury, within brain-derived tumors, and around brain tumors.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

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