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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.4 P.249-253

http://doi.org/10.1631/jzus.2005.B0249


The effects of sotalol on ventricular repolarization during exercise


Author(s):  LI Jian, WANG Jian-an

Affiliation(s):  Cardiology Department of Pu Nan Hospital, Pudong New District, Shanghai 200125, China; more

Corresponding email(s):   lj.zj@126.com, swordzj_cn@sina.com

Key Words:  Sotalol, Exercise stress test, Ventricular repolarization


LI Jian, WANG Jian-an. The effects of sotalol on ventricular repolarization during exercise[J]. Journal of Zhejiang University Science B, 2005, 6(4): 249-253.

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author="LI Jian, WANG Jian-an",
journal="Journal of Zhejiang University Science B",
volume="6",
number="4",
pages="249-253",
year="2005",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2005.B0249"
}

%0 Journal Article
%T The effects of sotalol on ventricular repolarization during exercise
%A LI Jian
%A WANG Jian-an
%J Journal of Zhejiang University SCIENCE B
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%P 249-253
%@ 1673-1581
%D 2005
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B0249

TY - JOUR
T1 - The effects of sotalol on ventricular repolarization during exercise
A1 - LI Jian
A1 - WANG Jian-an
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 4
SP - 249
EP - 253
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B0249


Abstract: 
Objective: Although after pacing animal and human studies have demonstrated a rate-dependent effect of sotalol on ventricular repolarization, there is little information on the effects of sotalol on ventricular repolarization during exercise. This study attempted to show the effects of sotalol on ventricular repolarization during physiological exercise. Methods: Thirty-one healthy volunteers (18 males, 13 females) were enrolled in the study. Each performed a maximal treadmill exercise test according to the Bruce protocol after random treatment with sotalol, propranolol and placebo. Results: sotalol significantly prolonged QTc (corrected QT) and JTc (corrected JT) intervals at rest compared with propranolol (QTc 324.86 ms vs 305.21 ms, P<0.001; JTc 245.04 ms vs 224.17 ms, P<0.001) and placebo (QTc 324.86 ms vs 314.06 ms, P<0.01; JTc 245.04 ms vs. 232.69 ms, P<0.001). The JTc percent reduction increased progressively with each stage of exercise and correlated positively with exercise heart rate (r=0.148, P<0.01). The JTc percent reduction correlation with exercise heart rate did not exist with either propranolol or placebo. Conclusions: These results imply that with sotalol ventricular repolarization is progressively shortened after exercise. Thus the specific class III antiarrhythmic activity of sotalol, present as delay of ventricular repolarization, may be attenuated during exercise. Such findings may imply the need to consider other antiarrythmic therapy during periods of stress-induced tachycardia.

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Reference

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