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Received: 2005-12-07

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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.2 P.99-106

http://doi.org/10.1631/jzus.2006.B0099


Early metabolism evaluation making traditional Chinese medicine effective and safe therapeutics


Author(s):  Liu Yong, Yang Ling

Affiliation(s):  Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, the Chinese Academy of Sciences, Dalian 116023, China

Corresponding email(s):   yling@dicp.ac.cn

Key Words:  Traditional Chinese medicine (TCM), Metabolism, Gastrointestinal biotransformation


Liu Yong, Yang Ling. Early metabolism evaluation making traditional Chinese medicine effective and safe therapeutics[J]. Journal of Zhejiang University Science B, 2006, 7(2): 99-106.

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author="Liu Yong, Yang Ling",
journal="Journal of Zhejiang University Science B",
volume="7",
number="2",
pages="99-106",
year="2006",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2006.B0099"
}

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%A Liu Yong
%A Yang Ling
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2006.B0099

TY - JOUR
T1 - Early metabolism evaluation making traditional Chinese medicine effective and safe therapeutics
A1 - Liu Yong
A1 - Yang Ling
J0 - Journal of Zhejiang University Science B
VL - 7
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SP - 99
EP - 106
%@ 1673-1581
Y1 - 2006
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2006.B0099


Abstract: 
Increasing attention is being paid to the scientific evaluation of traditional Chinese medicine (TCM). As many TCMs are capable of biotransformation in the gastrointestinal tract, attention to biotransformation of TCM in the gastrointestinal tract may lead to discovery of the active components and active mechanisms. In this article, we review reports that host metabolic enzymes and intestinal bacteria may be responsible for the metabolism of TCM. Good understanding of the in vivo course of TCM will help us to know how to conduct metabolism evaluation of TCM by using in vitro human-derived system. This evaluation system will create new views on TCM as effective and safe therapeutic agents.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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