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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.12 P.947-956


Activity optimization method in SPECT: A comparison with ROC analysis

Author(s):  DÍ,AZ Marlé,n Pé,rez, RIZO Oscar Dí,az, DÍ,AZ Adlin Ló,pez, APARICIO Eric Esté,vez, DÍ,AZ Reinaldo Roque

Affiliation(s):  Center for Studies on Electronics & Info Tech. Images Group, Central University of Las Villas, Santa Clara 54830, Cuba; more

Corresponding email(s):   mperez@uclv.edu.cu

Key Words:  Activity optimization, Image quality, SPECT, Discriminant analysis, ROC curves

DÍAZ Marlén Pérez, RIZO Oscar Díaz, DÍAZ Adlin López, APARICIO Eric Estévez, DÍAZ Reinaldo Roque. Activity optimization method in SPECT: A comparison with ROC analysis[J]. Journal of Zhejiang University Science B, 2006, 7(12): 947-956.

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journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%DOI 10.1631/jzus.2006.B0947

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DOI - 10.1631/jzus.2006.B0947

A discriminant method for optimizing activity in nuclear medicine studies is validated by comparison with ROC (received operating characteristic)-curves. The method is tested in 21 single photon emission computerized tomography (SPECT), performed with a cardiac phantom. Three different lesions (L1, L2 and L3) were placed in the myocardium-wall by pairs for each SPECT. Three activities (84, 37 or 18.5 MBq) of 99mTc were used as background. Linear discriminant analysis was used to select the parameters that characterize image quality among the measured variables in the images [(Background-to-Lesion (B/Li) and Signal-to-Noise (Si/N) ratios)]. Two clusters with different image quality (P=0.021) were obtained. The ratios B/L1, B/L2 and B/L3 are the parameters used to construct the function with 100% of cases correctly classified into the clusters. The value of 37 MBq was the lowest tested activity for which good results for the B/Li ratios were obtained. The result coincides with the applied ROC-analysis (r=0.89).

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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