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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.6 P.446-452

http://doi.org/10.1631/jzus.2007.B0446


Synthesis of Schiff bases of naphtha[1,2-d]thiazol-2-amine and metal complexes of 2-(2'-hydroxy)benzylideneaminonaphthothiazole as potential antimicrobial agents


Author(s):  AZAM Faizul, SINGH Satendra, KHOKHRA Sukhbir Lal, PRAKASH Om

Affiliation(s):  Department of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana 136119, India; more

Corresponding email(s):   faizulazam@gmail.com

Key Words:  Schiff bases, Metal complexes, Antimicrobial


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AZAM Faizul, SINGH Satendra, KHOKHRA Sukhbir Lal, PRAKASH Om. Synthesis of Schiff bases of naphtha[1,2-d]thiazol-2-amine and metal complexes of 2-(2'-hydroxy)benzylideneaminonaphthothiazole as potential antimicrobial agents[J]. Journal of Zhejiang University Science B, 2007, 8(6): 446-452.

@article{title="Synthesis of Schiff bases of naphtha[1,2-d]thiazol-2-amine and metal complexes of 2-(2'-hydroxy)benzylideneaminonaphthothiazole as potential antimicrobial agents",
author="AZAM Faizul, SINGH Satendra, KHOKHRA Sukhbir Lal, PRAKASH Om",
journal="Journal of Zhejiang University Science B",
volume="8",
number="6",
pages="446-452",
year="2007",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2007.B0446"
}

%0 Journal Article
%T Synthesis of Schiff bases of naphtha[1,2-d]thiazol-2-amine and metal complexes of 2-(2'-hydroxy)benzylideneaminonaphthothiazole as potential antimicrobial agents
%A AZAM Faizul
%A SINGH Satendra
%A KHOKHRA Sukhbir Lal
%A PRAKASH Om
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 6
%P 446-452
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0446

TY - JOUR
T1 - Synthesis of Schiff bases of naphtha[1,2-d]thiazol-2-amine and metal complexes of 2-(2'-hydroxy)benzylideneaminonaphthothiazole as potential antimicrobial agents
A1 - AZAM Faizul
A1 - SINGH Satendra
A1 - KHOKHRA Sukhbir Lal
A1 - PRAKASH Om
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 6
SP - 446
EP - 452
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0446


Abstract: 
Objective: A series of 2-benzylideneaminonaphthothiazoles were designed and synthesized incorporating the lipophilic naphthalene ring to render them more capable of penetrating various biomembranes. Methods: schiff bases were synthesized by the reaction of naphtha[1,2-d]thiazol-2-amine with various substituted aromatic aldehydes. 2-(2'-Hydroxy)benzylideneaminonaphthothiazole was converted to its Co(II), Ni(II) and Cu(II) metal complexes upon treatment with metal salts in ethanol. All the compounds were evaluated for their antibacterial activities by paper disc diffusion method with Gram positive Staphylococcus aureus and Staphylococcus epidermidis and Gram negative Escherichia coli and Pseudomonas aeruginosa bacteria. The minimum inhibitory concentrations of all the schiff bases and metal complexes were determined by agar streak dilution method. Results: All the compounds moderately inhibited the growth of Gram positive and Gram negative bacteria. In the present study among all schiff bases 2-(2'-hydroxy)benzylideneaminonaphthothiazole showed maximum inhibitory activity and among metal complexes Cu(II) metal complex was found to be most potent. Conclusion: The results obtained validate the hypothesis that schiff bases having substitution with halogens, hydroxyl group and nitro group at phenyl ring are required for the antibacterial activity while methoxy group at different positions in the aromatic ring has minimal role in the inhibitory activity. The results also indicated that the metal complexes are better antibacterial agents as compared to the schiff bases.

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