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Journal of Zhejiang University SCIENCE B 2008 Vol.9 No.11 P.853-856

http://doi.org/10.1631/jzus.B0820069


Investigation of stressful life events in patients with systemic sclerosis


Author(s):  Yue CHEN, Ji-zhong HUANG, Yu QIANG, Jin WANG, Mao-mao HAN

Affiliation(s):  Department of Geriatrics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   lxling@mail.hz.zj.cn

Key Words:  Systemic sclerosis (SSc), Life events, Stress, Pathogenesis


Yue CHEN, Ji-zhong HUANG, Yu QIANG, Jin WANG, Mao-mao HAN. Investigation of stressful life events in patients with systemic sclerosis[J]. Journal of Zhejiang University Science B, 2008, 9(11): 853-856.

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author="Yue CHEN, Ji-zhong HUANG, Yu QIANG, Jin WANG, Mao-mao HAN",
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820069

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T1 - Investigation of stressful life events in patients with systemic sclerosis
A1 - Yue CHEN
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DOI - 10.1631/jzus.B0820069


Abstract: 
Objective: To assess the occurrence of stressful life events in the year before the initiation of systemic sclerosis. Methods: A consecutive series of 40 patients with systemic sclerosis (mean age (56.3±11.9) years, mean disease duration (4.3±3.1) years; 32 females and 8 males), including 28 with diffuse cutaneous scleroderma and 12 with limited cutaneous scleroderma, were evaluated. A control group of 40 healthy subjects free of systemic sclerosis also was included. Socioeconomic status was investigated and Paykel’s interview for recent life events (a semi-structured research interview covering 64 life events) was conducted. Results: Patients with systemic sclerosis showed higher percentages of lower education (72.5%) and working class (82.5%), and reported more stressful life events (P<0.05), such as exits (P<0.05), undesirable events (P<0.01), and uncontrolled events (P<0.001), when compared with the control. More events that had an objective negative impact (P<0.001) were also reported in systemic sclerosis patients than in the control. These results are in accordance with a multifactorial model of pathogenesis in systemic sclerosis. Conclusion: We reported a strong relationship between stressful life events and the initiation of systemic sclerosis. Our findings are consistent with current understanding of the extensive links of behavioral responses to stress with neurophysiological and biochemical processes.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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