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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.5 P.315-322


Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7

Author(s):  Eun-Jin Yang, Ji-Young Moon, Min-Jin Kim, Dong Sam Kim, Chan-Shick Kim, Wook Jae Lee, Nam Ho Lee, Chang-Gu Hyun

Affiliation(s):  Jeju Biodiversity Research Institute (JBRI), Jeju High-Tech Development Institute (HiDI), Jeju 699-943, Korea, Jeju Seaweed Industry Development Agency, Cheju National University, Jeju 690-756, Korea, Faculty of Biotechnology, Cheju National University, Jeju 690-756, Korea, Department of Chemistry, Cheju National University, Jeju 690-756, Korea

Corresponding email(s):   cghyun@jejuhidi.or.kr

Key Words:  Nitric oxide, Interleukin-6 (IL-6), Prostaglandin E2 (PGE2), Tumor necrosis factor-α, (TNF-α, ), Seaweeds, Pro-inflammatory mediators

Eun-Jin Yang, Ji-Young Moon, Min-Jin Kim, Dong Sam Kim, Chan-Shick Kim, Wook Jae Lee, Nam Ho Lee, Chang-Gu Hyun. Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7[J]. Journal of Zhejiang University Science B, 2010, 11(5): 315-322.

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author="Eun-Jin Yang, Ji-Young Moon, Min-Jin Kim, Dong Sam Kim, Chan-Shick Kim, Wook Jae Lee, Nam Ho Lee, Chang-Gu Hyun",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7
%A Eun-Jin Yang
%A Ji-Young Moon
%A Min-Jin Kim
%A Dong Sam Kim
%A Chan-Shick Kim
%A Wook Jae Lee
%A Nam Ho Lee
%A Chang-Gu Hyun
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 5
%P 315-322
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0900364

T1 - Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7
A1 - Eun-Jin Yang
A1 - Ji-Young Moon
A1 - Min-Jin Kim
A1 - Dong Sam Kim
A1 - Chan-Shick Kim
A1 - Wook Jae Lee
A1 - Nam Ho Lee
A1 - Chang-Gu Hyun
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 5
SP - 315
EP - 322
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B0900364

Seaweed has been used in traditional cosmetics and as a herbal medicine in treatments for cough, boils, goiters, stomach ailments, and urinary diseases, and for reducing the incidence of tumors, ulcers, and headaches. Despite the fact that seaweeds are frequently used in the practice of human health, little is known about the role of seaweed in the context of inflammation. This study aimed to investigate the influence of Jeju endemic seaweed on a mouse macrophage cell line (RAW 264.7) under the stimulation of lipopolysaccharide (LPS). Ethyl acetate extracts obtained from 14 different kinds of Jeju seaweeds were screened for inhibitory effects on pro-inflammatory mediators. Our results revealed that extracts from five seaweeds, Laurencia okamurae, Grateloupia elliptica, Sargassum thunbergii, Gloiopeltis furcata, and Hizikia fusiformis, were potent inhibitors of the production of pro-inflammatory mediators such as nitric oxide (NO), )%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>prostaglandin E2 (PGE2), )%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>interleukin-6 (IL-6), and tumor necrosis factor-α; (TNF-α;). Based on these results, the anti-inflammatory effects and low cell toxicity of these seaweed extracts suggest potential therapeutic applications in the regulation of the inflammatory response.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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