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On-line Access: 2011-04-06

Received: 2010-05-10

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Crosschecked: 2011-01-25

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.4 P.280-286


Inflammatory bowel disease unclassified

Author(s):  Ning Zhou, Wei-xing Chen, Shao-hua Chen, Cheng-fu Xu, You-ming Li

Affiliation(s):  Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   zlym@zju.edu.cn

Key Words:  Inflammatory bowel disease unclassified, Ulcerative colitis, Crohn’, s disease, Subtype, Diagnosis

Ning Zhou, Wei-xing Chen, Shao-hua Chen, Cheng-fu Xu, You-ming Li. Inflammatory bowel disease unclassified[J]. Journal of Zhejiang University Science B, 2011, 12(4): 280-286.

@article{title="Inflammatory bowel disease unclassified",
author="Ning Zhou, Wei-xing Chen, Shao-hua Chen, Cheng-fu Xu, You-ming Li",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Inflammatory bowel disease unclassified
%A Ning Zhou
%A Wei-xing Chen
%A Shao-hua Chen
%A Cheng-fu Xu
%A You-ming Li
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 4
%P 280-286
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000172

T1 - Inflammatory bowel disease unclassified
A1 - Ning Zhou
A1 - Wei-xing Chen
A1 - Shao-hua Chen
A1 - Cheng-fu Xu
A1 - You-ming Li
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 4
SP - 280
EP - 286
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000172

Objective: Inflammatory bowel diseases (IBDs) are idiopathic, chronic, and inflammatory intestinal disorders. The two main types, ulcerative colitis (UC) and crohn’;s disease (CD), sometimes mimic each other and are not readily distinguishable. The purpose of this study was to present a series of hospitalized cases, which could not initially be classified as a subtype of IBD, and to try to note roles of the terms indeterminate colitis (IC) and inflammatory bowel disease unclassified (IBDU) when such a dilemma arises. Methods: Medical records of 477 patients hospitalized due to IBD, during the period of January 2002 to April 2009, were retrospectively studied in the present paper. All available previous biopsies from endoscopies of these patients were reanalyzed. Results: Twenty-seven of 477 IBD patients (5.7%) had been initially diagnosed as having IBDU. Of them, 23 received colonoscopy and histological examinations in our hospital. A total of 90% (9/10) and 66.7% (4/6) of patients, respectively, had a positive finding via wireless capsule endoscopy (CE) and double-balloon enteroscopy (DBE). The barium-swallow or small bowel follow-through (SBFT) was performed on 11 patients. Positive changes were observed under computer tomographic (CT) scanning in 89.5% (17/19) of patients. Reasonable treatment strategies were employed for all patients. Conclusions: Our data indicate that IBDU accounts for 5.7% of initial diagnoses of IBD. The definition of IBDU is valuable in clinical practice. For those who had no clear clinical, endoscopic, histological, or other features affording a diagnosis of either UC or CD, IBDU could be used parenthetically.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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