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CLC number: R69

On-line Access: 2011-06-07

Received: 2010-10-17

Revision Accepted: 2011-02-13

Crosschecked: 2011-04-28

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.6 P.455-459


Effect of tadalafil in chronic renal failure rabbits: relevance to erectile dysfunction

Author(s):  Meng-yuan Zhang, Qiang Fu, Wei Bian

Affiliation(s):  Department of Urology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China

Corresponding email(s):   im_fuqiang@yahoo.com

Key Words:  Chronic renal failure, Erectile dysfunction, Phosphodiesterase inhibitor, Tadalafil

Meng-yuan Zhang, Qiang Fu, Wei Bian. Effect of tadalafil in chronic renal failure rabbits: relevance to erectile dysfunction[J]. Journal of Zhejiang University Science B, 2011, 12(6): 455-459.

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author="Meng-yuan Zhang, Qiang Fu, Wei Bian",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Effect of tadalafil in chronic renal failure rabbits: relevance to erectile dysfunction
%A Meng-yuan Zhang
%A Qiang Fu
%A Wei Bian
%J Journal of Zhejiang University SCIENCE B
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%N 6
%P 455-459
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000363

T1 - Effect of tadalafil in chronic renal failure rabbits: relevance to erectile dysfunction
A1 - Meng-yuan Zhang
A1 - Qiang Fu
A1 - Wei Bian
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 6
SP - 455
EP - 459
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000363

It is of great importance to investigate an effective and reliable medication against chronic renal failure (CRF)-related erectile dysfunction (ED), which aims to improve patients’ life qualities. The concentrations of cyclic guanosine monophosphate (cGMP) in the corpus cavernosal smooth muscle of both CRF and control rabbits were measured. The effects of various concentrations of tadalafil, papaverine, and sodium nitroprusside on the relaxation responses of corpus cavernosal smooth muscle pre-contracted with phenylephrine in CRF rabbits were observed. There was significant difference in the concentration of cGMP between CRF and control rabbits (P<0.01). tadalafil had the greatest impacts on CRF rabbits when given the same concentration of papaverine or sodium nitroprusside and particularly significant differences were identified under the concentration levels of 10−5 and 10−4 mol/L (P<0.01). The results suggest that the cGMP concentrations of the corpus cavernosum had been greatly reduced in CRF rabbits compared with control rabbits and that tadalafil may be an ideal medication for use in the treatment of CRF-related ED.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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